LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Palbociclib 45.74 11.9
0.3222
0.2829
 0.0596 0.0913 1.1227 0.3742
MCF 10A-H2B-mCherry Trametinib 37.23 11.9
0.0043
0.0042
 0.0602 0.0536 1.0579 0.6101
MCF 10A-H2B-mCherry Dasatinib 18.49 11.9
Inf
Inf
 0.0602 -0.3489 0.2088 0.4503
MCF 10A-H2B-mCherry Trametinib 33.82 11.9
0.003
0.0026
 0.0616 0.1292 1.6293 0.6149
MCF 10A-H2B-mCherry Trametinib 42.33 11.9
0.0059
0.0053
 0.0648 0.0806 1.0732 0.5725
MCF 10A-H2B-mCherry Palbociclib 30.41 11.9
0.2416
0.1935
 0.0651 0.1034 1.0430 0.3982
MCF 10A-H2B-mCherry Palbociclib 27.00 11.9
0.1687
0.1544
 0.0778 0.1703 3.2433 0.4239
MCF 10A-H2B-mCherry Trametinib 85.43 12.0
Inf
Inf
 0.0802 0.0802 0.0000 0.6023
MCF 10A-H2B-mCherry Trametinib 28.71 11.9
0.0019
0.0014
 0.0832 0.1492 1.8509 0.6520
MCF 10A-H2B-mCherry Dasatinib 16.79 11.9
Inf
Inf
 0.0863 -0.4330 0.2049 0.4204
MCF 10A-H2B-mCherry Trametinib 30.41 11.9
0.0023
0.0017
 0.0870 0.1475 1.2021 0.6335
MCF 10A-H2B-mCherry Trametinib 35.52 11.9
0.0036
0.0031
 0.0908 0.0944 1.1733 0.6178
MCF 10A-H2B-mCherry Palbociclib 21.90 11.9
0.1028
3.6973
 0.0917 -0.2900 0.4483 0.4878
MCF 10A-H2B-mCherry Palbociclib 25.30 11.9
0.1483
0.1392
 0.0934 0.1739 3.2748 0.4447
MCF 10A-H2B-mCherry Palbociclib 20.19 11.9
0.1053
23.8386
 0.1006 -0.3621 0.3848 0.4707
MCF 10A-H2B-mCherry Trametinib 25.30 11.9
0.0017
0.0014
 0.1022 0.1419 1.1785 0.6613
MCF 10A-H2B-mCherry Vorinostat 69.60 11.9
4.6605
4.5982
 0.1156 0.0327 5.0000 0.1150
MCF 10A-H2B-mCherry Palbociclib 16.79 11.9
Inf
Inf
 0.1194 -0.3957 0.0878 0.4436
MCF 10A-H2B-mCherry Dasatinib 15.08 11.9
Inf
Inf
 0.1243 -0.4244 0.2057 0.3924
MCF 10A-H2B-mCherry Neratinib 15.08 11.9
0.0426
0.0275
 0.1256 0.3067 3.0534 0.4072
MCF 10A-H2B-mCherry Vorinostat 85.43 12.0
Inf
Inf
 0.1293 0.1293 0.0000 0.6446
MCF 10A-H2B-mCherry Neratinib 85.43 11.9
Inf
Inf
 0.1308 0.1308 0.0000 0.4931
MCF 10A-H2B-mCherry Taxol 71.30 11.9
0.001
0.0014
 0.1323 -0.2625 3.2812 0.7769
MCF 10A-H2B-mCherry Palbociclib 15.08 11.9
Inf
Inf
 0.1532 0.1532 0.0000 0.4065
MCF 10A-H2B-mCherry Trametinib 80.31 11.9
Inf
Inf
 0.1537 0.1537 0.0000 0.4652