LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Neratinib | 16.79 | 11.9 | 0.0408 | 0.0286 | 0.0286 | 0.2638 | 3.0072 | 0.4249 |
| MCF 10A-H2B-mCherry | Etoposide | 28.71 | 11.9 | 0.282 | 0.2635 | 0.0303 | 0.0409 | 1.1655 | 0.3976 |
| MCF 10A-H2B-mCherry | Etoposide | 30.41 | 11.9 | 0.2534 | 0.2242 | 0.0315 | 0.0751 | 1.2997 | 0.3958 |
| MCF 10A-H2B-mCherry | Palbociclib | 47.45 | 11.9 | 0.4007 | 0.3571 | 0.0316 | 0.0791 | 1.1944 | 0.3387 |
| MCF 10A-H2B-mCherry | Etoposide | 23.60 | 11.9 | 0.4333 | 0.3681 | 0.0325 | 0.0929 | 0.9623 | 0.3221 |
| MCF 10A-H2B-mCherry | Dasatinib | 21.90 | 11.9 | 0.1528 | 0.2547 | 0.0327 | -0.0888 | 0.5237 | 0.4742 |
| MCF 10A-H2B-mCherry | Palbociclib | 35.52 | 11.9 | 0.3131 | 0.7629 | 0.0347 | -0.1254 | 0.6828 | 0.3821 |
| MCF 10A-H2B-mCherry | Palbociclib | 38.93 | 11.9 | 0.3215 | 0.6362 | 0.0367 | -0.0968 | 0.8082 | 0.3640 |
| MCF 10A-H2B-mCherry | Etoposide | 20.19 | 11.9 | 1.0484 | 6.2551 | 0.0379 | -0.5651 | 0.6316 | 0.2770 |
| MCF 10A-H2B-mCherry | Dasatinib | 20.19 | 11.9 | 0.1745 | 0.6356 | 0.0392 | -0.1961 | 0.3732 | 0.4695 |
| MCF 10A-H2B-mCherry | Dasatinib | 23.60 | 11.9 | 0.1781 | 0.1699 | 0.0396 | 0.0416 | 0.6705 | 0.4476 |
| MCF 10A-H2B-mCherry | Etoposide | 15.08 | 11.9 | Inf | Inf | 0.0410 | -0.3362 | 0.4618 | 0.2363 |
| MCF 10A-H2B-mCherry | Palbociclib | 40.63 | 11.9 | 0.3215 | 0.6528 | 0.0417 | -0.0527 | 1.0490 | 0.3538 |
| MCF 10A-H2B-mCherry | Palbociclib | 44.03 | 11.9 | 0.2647 | 0.2203 | 0.0439 | 0.1171 | 1.2416 | 0.3844 |
| MCF 10A-H2B-mCherry | Palbociclib | 33.82 | 11.9 | 0.3333 | 0.5123 | 0.0442 | -0.0905 | 0.6772 | 0.3797 |
| MCF 10A-H2B-mCherry | Trametinib | 85.43 | 11.9 | Inf | Inf | 0.0455 | 0.0455 | 0.0000 | 0.6300 |
| MCF 10A-H2B-mCherry | Palbociclib | 37.23 | 11.9 | 0.3111 | 1.7194 | 0.0455 | -0.2613 | 0.6493 | 0.3859 |
| MCF 10A-H2B-mCherry | Trametinib | 27.00 | 11.9 | 0.0019 | 0.0016 | 0.0473 | 0.1162 | 1.2836 | 0.6659 |
| MCF 10A-H2B-mCherry | Dasatinib | 25.30 | 11.9 | 0.1978 | 0.2226 | 0.0489 | 0.0284 | 0.7503 | 0.4393 |
| MCF 10A-H2B-mCherry | Palbociclib | 32.11 | 11.9 | 0.3007 | 0.3037 | 0.0493 | 0.0030 | 0.8310 | 0.3877 |
| MCF 10A-H2B-mCherry | Trametinib | 32.11 | 11.9 | 0.0031 | 0.0024 | 0.0500 | 0.1203 | 1.1430 | 0.6178 |
| MCF 10A-H2B-mCherry | Palbociclib | 28.71 | 11.9 | 0.1921 | 0.1743 | 0.0502 | 0.1399 | 2.7597 | 0.4197 |
| MCF 10A-H2B-mCherry | Palbociclib | 18.49 | 11.9 | Inf | Inf | 0.0520 | -0.4305 | 0.1045 | 0.4625 |
| MCF 10A-H2B-mCherry | Palbociclib | 23.60 | 11.9 | 0.1293 | 4.9077 | 0.0535 | -0.4107 | 0.6847 | 0.4909 |
| MCF 10A-H2B-mCherry | Trametinib | 40.63 | 11.9 | 0.0072 | 0.0068 | 0.0540 | 0.0361 | 1.0427 | 0.5699 |