LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 28.71 | 11.9 | 0.0019 | 0.0014 | 0.0832 | 0.1492 | 1.8509 | 0.6520 |
| MCF 10A-H2B-mCherry | Alpelisib | 45.74 | 11.9 | Inf | Inf | 0.8089 | 0.1521 | 0.3040 | 0.0556 |
| MCF 10A-H2B-mCherry | Palbociclib | 15.08 | 11.9 | Inf | Inf | 0.1532 | 0.1532 | 0.0000 | 0.4065 |
| MCF 10A-H2B-mCherry | Trametinib | 80.31 | 11.9 | Inf | Inf | 0.1537 | 0.1537 | 0.0000 | 0.4652 |
| MCF 10A-H2B-mCherry | Palbociclib | 27.00 | 11.9 | 0.1687 | 0.1544 | 0.0778 | 0.1703 | 3.2433 | 0.4239 |
| MCF 10A-H2B-mCherry | Palbociclib | 25.30 | 11.9 | 0.1483 | 0.1392 | 0.0934 | 0.1739 | 3.2748 | 0.4447 |
| MCF 10A-H2B-mCherry | Trametinib | 23.60 | 11.9 | 0.0013 | 0.0015 | 0.2225 | 0.1793 | 1.2585 | 0.6490 |
| MCF 10A-H2B-mCherry | Vorinostat | 85.43 | 11.9 | Inf | Inf | 0.1827 | 0.1827 | 0.0000 | 0.6413 |
| MCF 10A-H2B-mCherry | Trametinib | 76.90 | 11.9 | Inf | Inf | 0.2209 | 0.2209 | 0.0000 | 0.3859 |
| MCF 10A-H2B-mCherry | Trametinib | 21.90 | 11.9 | 0.0013 | 0.0014 | 0.1822 | 0.2336 | 1.5224 | 0.6197 |
| MCF 10A-H2B-mCherry | Neratinib | 16.79 | 11.9 | 0.0408 | 0.0286 | 0.0286 | 0.2638 | 3.0072 | 0.4249 |
| MCF 10A-H2B-mCherry | Neratinib | 15.08 | 11.9 | 0.0426 | 0.0275 | 0.1256 | 0.3067 | 3.0534 | 0.4072 |
| MCF 10A-H2B-mCherry | Taxol | 69.60 | 11.9 | Inf | Inf | 0.6450 | 0.3071 | 2.4999 | 0.7524 |
| MCF 10A-H2B-mCherry | Trametinib | 15.08 | 11.9 | Inf | Inf | 0.3411 | 0.3411 | 0.0000 | 0.3691 |
| MCF 10A-H2B-mCherry | Trametinib | 20.19 | 11.9 | 0.0012 | 0.0012 | 0.2434 | 0.3423 | 3.2856 | 0.5482 |
| MCF 10A-H2B-mCherry | Alpelisib | 42.33 | 11.9 | Inf | 10.3523 | 0.7387 | 0.3591 | 3.2502 | 0.0201 |
| MCF 10A-H2B-mCherry | Trametinib | 18.49 | 11.9 | Inf | Inf | 0.3116 | 0.3689 | 2.5000 | 0.4518 |
| MCF 10A-H2B-mCherry | Alpelisib | 21.90 | 11.9 | Inf | Inf | 0.4426 | 0.4238 | 2.5000 | 0.1686 |
| MCF 10A-H2B-mCherry | Trametinib | 16.79 | 11.9 | Inf | Inf | 0.4137 | 0.4380 | 0.6914 | 0.4102 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.19 | 11.9 | Inf | Inf | 0.4666 | 0.4567 | 2.5000 | 0.1534 |
| MCF 10A-H2B-mCherry | Alpelisib | 15.08 | 11.9 | Inf | Inf | 0.4895 | 0.4895 | 0.0000 | 0.1563 |
| MCF 10A-H2B-mCherry | Alpelisib | 23.60 | 11.9 | Inf | Inf | 0.5168 | 0.4975 | 2.5000 | 0.1285 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.49 | 11.9 | Inf | Inf | 0.4464 | 0.5217 | 2.5000 | 0.1547 |
| MCF 10A-H2B-mCherry | Alpelisib | 25.30 | 11.9 | Inf | 2.7919 | 0.5162 | 0.5717 | 4.5032 | 0.1028 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.79 | 11.9 | Inf | Inf | 0.4687 | 0.5844 | 2.5000 | 0.1607 |