LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Etoposide 25.30 11.9
0.3804
0.3361
 0.0269 0.0627 1.0177 0.3559
MCF 10A-H2B-mCherry Etoposide 32.11 11.9
0.2448
0.2218
 0.0235 0.0692 1.4555 0.3981
MCF 10A-H2B-mCherry Trametinib 73.49 11.9
Inf
Inf
 -0.1619 0.0708 2.5000 0.4352
MCF 10A-H2B-mCherry Palbociclib 49.15 11.9
0.4833
0.4274
 -0.0214 0.0727 1.1331 0.3149
MCF 10A-H2B-mCherry Etoposide 30.41 11.9
0.2534
0.2242
 0.0315 0.0751 1.2997 0.3958
MCF 10A-H2B-mCherry Trametinib 38.93 11.9
0.0062
0.0061
 0.0264 0.0759 1.1491 0.5681
MCF 10A-H2B-mCherry Palbociclib 47.45 11.9
0.4007
0.3571
 0.0316 0.0791 1.1944 0.3387
MCF 10A-H2B-mCherry Trametinib 85.43 12.0
Inf
Inf
 0.0802 0.0802 0.0000 0.6023
MCF 10A-H2B-mCherry Trametinib 42.33 11.9
0.0059
0.0053
 0.0648 0.0806 1.0732 0.5725
MCF 10A-H2B-mCherry Palbociclib 45.74 11.9
0.3222
0.2829
 0.0596 0.0913 1.1227 0.3742
MCF 10A-H2B-mCherry Etoposide 23.60 11.9
0.4333
0.3681
 0.0325 0.0929 0.9623 0.3221
MCF 10A-H2B-mCherry Trametinib 35.52 11.9
0.0036
0.0031
 0.0908 0.0944 1.1733 0.6178
MCF 10A-H2B-mCherry Palbociclib 30.41 11.9
0.2416
0.1935
 0.0651 0.1034 1.0430 0.3982
MCF 10A-H2B-mCherry Neratinib 20.19 11.9
0.0265
0.0223
 -0.1108 0.1112 1.3534 0.5062
MCF 10A-H2B-mCherry Trametinib 27.00 11.9
0.0019
0.0016
 0.0473 0.1162 1.2836 0.6659
MCF 10A-H2B-mCherry Palbociclib 44.03 11.9
0.2647
0.2203
 0.0439 0.1171 1.2416 0.3844
MCF 10A-H2B-mCherry Trametinib 32.11 11.9
0.0031
0.0024
 0.0500 0.1203 1.1430 0.6178
MCF 10A-H2B-mCherry Trametinib 33.82 11.9
0.003
0.0026
 0.0616 0.1292 1.6293 0.6149
MCF 10A-H2B-mCherry Vorinostat 85.43 12.0
Inf
Inf
 0.1293 0.1293 0.0000 0.6446
MCF 10A-H2B-mCherry Neratinib 18.49 11.9
0.0349
0.027
 -0.0435 0.1298 0.9796 0.4721
MCF 10A-H2B-mCherry Neratinib 85.43 11.9
Inf
Inf
 0.1308 0.1308 0.0000 0.4931
MCF 10A-H2B-mCherry Palbociclib 28.71 11.9
0.1921
0.1743
 0.0502 0.1399 2.7597 0.4197
MCF 10A-H2B-mCherry Palbociclib 42.33 11.9
0.2238
0.2
 0.0225 0.1406 2.3287 0.3776
MCF 10A-H2B-mCherry Trametinib 25.30 11.9
0.0017
0.0014
 0.1022 0.1419 1.1785 0.6613
MCF 10A-H2B-mCherry Trametinib 30.41 11.9
0.0023
0.0017
 0.0870 0.1475 1.2021 0.6335