LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 27.00 | 11.9 | Inf | Inf | 0.6407 | 0.6557 | 0.5188 | 0.0807 |
| MCF 10A-H2B-mCherry | Alpelisib | 71.30 | 11.9 | Inf | Inf | 0.8057 | 0.8057 | 0.0000 | 0.0922 |
| MCF 10A-H2B-mCherry | Alpelisib | 25.30 | 11.9 | Inf | 2.7919 | 0.5162 | 0.5717 | 4.5032 | 0.1028 |
| MCF 10A-H2B-mCherry | Vorinostat | 67.89 | 11.9 | 4.2349 | 4.3812 | -0.0390 | -0.0945 | 5.0000 | 0.1111 |
| MCF 10A-H2B-mCherry | Vorinostat | 69.60 | 11.9 | 4.6605 | 4.5982 | 0.1156 | 0.0327 | 5.0000 | 0.1150 |
| MCF 10A-H2B-mCherry | Vorinostat | 66.19 | 11.9 | 3.8965 | 3.9966 | -0.0930 | -0.0813 | 5.0000 | 0.1174 |
| MCF 10A-H2B-mCherry | Alpelisib | 23.60 | 11.9 | Inf | Inf | 0.5168 | 0.4975 | 2.5000 | 0.1285 |
| MCF 10A-H2B-mCherry | Vorinostat | 64.49 | 11.9 | 3.3049 | 3.3509 | -0.1239 | -0.0516 | 5.0000 | 0.1317 |
| MCF 10A-H2B-mCherry | Vorinostat | 62.78 | 11.9 | 2.7049 | 2.7752 | -0.0004 | -0.0435 | 2.2956 | 0.1473 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.19 | 11.9 | Inf | Inf | 0.4666 | 0.4567 | 2.5000 | 0.1534 |
| MCF 10A-H2B-mCherry | Alpelisib | 73.49 | 11.9 | Inf | Inf | -0.1025 | -0.1025 | 0.0000 | 0.1541 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.49 | 11.9 | Inf | Inf | 0.4464 | 0.5217 | 2.5000 | 0.1547 |
| MCF 10A-H2B-mCherry | Alpelisib | 15.08 | 11.9 | Inf | Inf | 0.4895 | 0.4895 | 0.0000 | 0.1563 |
| MCF 10A-H2B-mCherry | Palbociclib | 73.49 | 11.9 | 3.8592 | 5.0055 | -0.9830 | -1.0000 | 4.3323 | 0.1600 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.79 | 11.9 | Inf | Inf | 0.4687 | 0.5844 | 2.5000 | 0.1607 |
| MCF 10A-H2B-mCherry | Vorinostat | 61.08 | 11.9 | 2.3764 | 2.5438 | -0.1126 | -0.0963 | 2.3719 | 0.1658 |
| MCF 10A-H2B-mCherry | Alpelisib | 21.90 | 11.9 | Inf | Inf | 0.4426 | 0.4238 | 2.5000 | 0.1686 |
| MCF 10A-H2B-mCherry | Palbociclib | 64.49 | 11.9 | 2.6977 | 3.6537 | -0.1909 | -0.3806 | 1.8197 | 0.1720 |
| MCF 10A-H2B-mCherry | Vorinostat | 57.67 | 11.9 | 2.3384 | 2.6827 | -0.0950 | -0.1809 | 2.9370 | 0.1725 |
| MCF 10A-H2B-mCherry | Palbociclib | 71.30 | 11.9 | Inf | Inf | -0.2922 | -0.3418 | 1.3773 | 0.1777 |
| MCF 10A-H2B-mCherry | Vorinostat | 59.37 | 11.9 | 2.1848 | 2.392 | -0.0905 | -0.1195 | 2.4477 | 0.1781 |
| MCF 10A-H2B-mCherry | Palbociclib | 69.60 | 11.9 | Inf | Inf | -0.4255 | -0.5524 | 1.2035 | 0.1809 |
| MCF 10A-H2B-mCherry | Vorinostat | 54.25 | 11.9 | 2.1006 | 2.42 | -0.1151 | -0.1804 | 2.8861 | 0.1820 |
| MCF 10A-H2B-mCherry | Palbociclib | 66.19 | 11.9 | 2.9246 | 3.7993 | -0.2597 | -0.4149 | 2.1235 | 0.1823 |
| MCF 10A-H2B-mCherry | Palbociclib | 67.89 | 11.9 | 3.5863 | 5.6185 | -0.3169 | -0.7077 | 1.9844 | 0.1842 |