LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 21.90 | 11.9 | 0.5423 | 0.8664 | -0.2962 | -0.3081 | 1.5323 | 0.4241 |
| MCF 10A-H2B-mCherry | Vorinostat | 18.49 | 11.9 | 0.5769 | 0.7432 | -0.3615 | -0.2481 | 1.6710 | 0.4087 |
| MCF 10A-H2B-mCherry | Vorinostat | 15.08 | 11.9 | 0.692 | 0.9855 | -0.3793 | -0.3371 | 1.5502 | 0.4019 |
| MCF 10A-H2B-mCherry | Vorinostat | 71.30 | 11.9 | Inf | Inf | 0.0118 | 0.0118 | 0.0000 | 0.1999 |
| MCF 10A-H2B-mCherry | Vorinostat | 67.89 | 11.9 | 4.2349 | 4.3812 | -0.0390 | -0.0945 | 5.0000 | 0.1111 |
| MCF 10A-H2B-mCherry | Vorinostat | 28.71 | 11.9 | 0.629 | 1.0433 | -0.2095 | -0.3356 | 1.1665 | 0.4172 |
| MCF 10A-H2B-mCherry | Vorinostat | 30.41 | 11.9 | 0.7329 | 1.0073 | -0.1849 | -0.2655 | 1.4478 | 0.3993 |
| MCF 10A-H2B-mCherry | Vorinostat | 33.82 | 11.9 | 0.8263 | 1.0452 | -0.1749 | -0.2229 | 1.5727 | 0.3726 |
| MCF 10A-H2B-mCherry | Vorinostat | 35.52 | 11.9 | 0.8203 | 1.1159 | -0.1907 | -0.2614 | 1.4527 | 0.3801 |
| MCF 10A-H2B-mCherry | Vorinostat | 40.63 | 11.9 | 1.1841 | 1.3562 | -0.1480 | -0.1647 | 2.5578 | 0.3101 |
| MCF 10A-H2B-mCherry | Vorinostat | 42.33 | 11.9 | 1.146 | 1.4165 | -0.1745 | -0.2133 | 1.8752 | 0.3130 |
| MCF 10A-H2B-mCherry | Vorinostat | 45.74 | 11.9 | 1.2871 | 1.7456 | -0.1825 | -0.2649 | 1.8103 | 0.3021 |
| MCF 10A-H2B-mCherry | Vorinostat | 47.45 | 11.9 | 1.449 | 1.8444 | -0.1922 | -0.2247 | 2.0346 | 0.2603 |
| MCF 10A-H2B-mCherry | Vorinostat | 54.25 | 11.9 | 2.1006 | 2.42 | -0.1151 | -0.1804 | 2.8861 | 0.1820 |
| MCF 10A-H2B-mCherry | Vorinostat | 55.97 | 11.9 | 2.1119 | 2.3545 | -0.1381 | -0.1723 | 3.1644 | 0.1856 |
| MCF 10A-H2B-mCherry | Trametinib | 21.90 | 11.9 | 0.0013 | 0.0014 | 0.1822 | 0.2336 | 1.5224 | 0.6197 |
| MCF 10A-H2B-mCherry | Trametinib | 20.19 | 11.9 | 0.0012 | 0.0012 | 0.2434 | 0.3423 | 3.2856 | 0.5482 |
| MCF 10A-H2B-mCherry | Trametinib | 23.60 | 11.9 | 0.0013 | 0.0015 | 0.2225 | 0.1793 | 1.2585 | 0.6490 |
| MCF 10A-H2B-mCherry | Trametinib | 16.79 | 11.9 | Inf | Inf | 0.4137 | 0.4380 | 0.6914 | 0.4102 |
| MCF 10A-H2B-mCherry | Trametinib | 15.08 | 11.9 | Inf | Inf | 0.3411 | 0.3411 | 0.0000 | 0.3691 |
| MCF 10A-H2B-mCherry | Trametinib | 18.49 | 11.9 | Inf | Inf | 0.3116 | 0.3689 | 2.5000 | 0.4518 |
| MCF 10A-H2B-mCherry | Trametinib | 25.30 | 11.9 | 0.0017 | 0.0014 | 0.1022 | 0.1419 | 1.1785 | 0.6613 |
| MCF 10A-H2B-mCherry | Trametinib | 89.69 | 11.9 | Inf | Inf | -0.1007 | -0.1007 | 0.0000 | 0.7813 |
| MCF 10A-H2B-mCherry | Trametinib | 27.00 | 11.9 | 0.0019 | 0.0016 | 0.0473 | 0.1162 | 1.2836 | 0.6659 |
| MCF 10A-H2B-mCherry | Trametinib | 73.49 | 11.9 | Inf | Inf | -0.1619 | 0.0708 | 2.5000 | 0.4352 |