LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 33.82 | 11.9 | 17.7359 | 26.237 | 0.6412 | -0.5037 | 1.1924 | 0.0475 |
| MCF 10A-H2B-mCherry | Alpelisib | 30.41 | 11.9 | Inf | 15.4577 | 0.6412 | -0.1329 | 1.0881 | 0.0751 |
| MCF 10A-H2B-mCherry | Alpelisib | 27.00 | 11.9 | Inf | Inf | 0.6407 | 0.6557 | 0.5188 | 0.0807 |
| MCF 10A-H2B-mCherry | Alpelisib | 35.52 | 11.9 | 17.5986 | 36.6414 | 0.6041 | -0.0856 | 2.8588 | 0.0554 |
| MCF 10A-H2B-mCherry | Vorinostat | 89.69 | 11.9 | Inf | Inf | 0.5920 | 0.5920 | 0.0000 | 0.6243 |
| MCF 10A-H2B-mCherry | Alpelisib | 23.60 | 11.9 | Inf | Inf | 0.5168 | 0.4975 | 2.5000 | 0.1285 |
| MCF 10A-H2B-mCherry | Alpelisib | 25.30 | 11.9 | Inf | 2.7919 | 0.5162 | 0.5717 | 4.5032 | 0.1028 |
| MCF 10A-H2B-mCherry | Alpelisib | 15.08 | 11.9 | Inf | Inf | 0.4895 | 0.4895 | 0.0000 | 0.1563 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.79 | 11.9 | Inf | Inf | 0.4687 | 0.5844 | 2.5000 | 0.1607 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.19 | 11.9 | Inf | Inf | 0.4666 | 0.4567 | 2.5000 | 0.1534 |
| MCF 10A-H2B-mCherry | Alpelisib | 18.49 | 11.9 | Inf | Inf | 0.4464 | 0.5217 | 2.5000 | 0.1547 |
| MCF 10A-H2B-mCherry | Alpelisib | 21.90 | 11.9 | Inf | Inf | 0.4426 | 0.4238 | 2.5000 | 0.1686 |
| MCF 10A-H2B-mCherry | Trametinib | 16.79 | 11.9 | Inf | Inf | 0.4137 | 0.4380 | 0.6914 | 0.4102 |
| MCF 10A-H2B-mCherry | Trametinib | 15.08 | 11.9 | Inf | Inf | 0.3411 | 0.3411 | 0.0000 | 0.3691 |
| MCF 10A-H2B-mCherry | Trametinib | 18.49 | 11.9 | Inf | Inf | 0.3116 | 0.3689 | 2.5000 | 0.4518 |
| MCF 10A-H2B-mCherry | Trametinib | 20.19 | 11.9 | 0.0012 | 0.0012 | 0.2434 | 0.3423 | 3.2856 | 0.5482 |
| MCF 10A-H2B-mCherry | Trametinib | 23.60 | 11.9 | 0.0013 | 0.0015 | 0.2225 | 0.1793 | 1.2585 | 0.6490 |
| MCF 10A-H2B-mCherry | Trametinib | 76.90 | 11.9 | Inf | Inf | 0.2209 | 0.2209 | 0.0000 | 0.3859 |
| MCF 10A-H2B-mCherry | Vorinostat | 85.43 | 11.9 | Inf | Inf | 0.1827 | 0.1827 | 0.0000 | 0.6413 |
| MCF 10A-H2B-mCherry | Trametinib | 21.90 | 11.9 | 0.0013 | 0.0014 | 0.1822 | 0.2336 | 1.5224 | 0.6197 |
| MCF 10A-H2B-mCherry | Trametinib | 80.31 | 11.9 | Inf | Inf | 0.1537 | 0.1537 | 0.0000 | 0.4652 |
| MCF 10A-H2B-mCherry | Palbociclib | 15.08 | 11.9 | Inf | Inf | 0.1532 | 0.1532 | 0.0000 | 0.4065 |
| MCF 10A-H2B-mCherry | Taxol | 71.30 | 11.9 | 0.001 | 0.0014 | 0.1323 | -0.2625 | 3.2812 | 0.7769 |
| MCF 10A-H2B-mCherry | Neratinib | 85.43 | 11.9 | Inf | Inf | 0.1308 | 0.1308 | 0.0000 | 0.4931 |
| MCF 10A-H2B-mCherry | Vorinostat | 85.43 | 12.0 | Inf | Inf | 0.1293 | 0.1293 | 0.0000 | 0.6446 |