LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 66.19 | 11.9 | 0.0293 | 0.0888 | -0.4739 | -0.4257 | 2.4814 | 0.4133 |
| MCF 10A-H2B-mCherry | Trametinib | 62.78 | 11.9 | 0.0231 | 0.0823 | -0.4067 | -0.4224 | 1.5981 | 0.4546 |
| MCF 10A-H2B-mCherry | Trametinib | 61.08 | 11.9 | 0.0225 | 0.0816 | -0.4094 | -0.4838 | 0.9123 | 0.4868 |
| MCF 10A-H2B-mCherry | Trametinib | 64.49 | 11.9 | 0.0231 | 0.0732 | -0.4390 | -0.3872 | 1.8528 | 0.4347 |
| MCF 10A-H2B-mCherry | Trametinib | 59.37 | 11.9 | 0.0199 | 0.0579 | -0.3026 | -0.3306 | 1.1156 | 0.4752 |
| MCF 10A-H2B-mCherry | Neratinib | 25.30 | 11.9 | 0.0433 | 0.0502 | -0.1661 | -0.0752 | 1.0775 | 0.5110 |
| MCF 10A-H2B-mCherry | Neratinib | 23.60 | 11.9 | 0.0306 | 0.0309 | -0.1485 | -0.0099 | 1.0173 | 0.5273 |
| MCF 10A-H2B-mCherry | Neratinib | 16.79 | 11.9 | 0.0408 | 0.0286 | 0.0286 | 0.2638 | 3.0072 | 0.4249 |
| MCF 10A-H2B-mCherry | Neratinib | 15.08 | 11.9 | 0.0426 | 0.0275 | 0.1256 | 0.3067 | 3.0534 | 0.4072 |
| MCF 10A-H2B-mCherry | Neratinib | 18.49 | 11.9 | 0.0349 | 0.027 | -0.0435 | 0.1298 | 0.9796 | 0.4721 |
| MCF 10A-H2B-mCherry | Trametinib | 55.97 | 11.9 | 0.0154 | 0.0232 | -0.2404 | -0.1358 | 1.0331 | 0.4994 |
| MCF 10A-H2B-mCherry | Neratinib | 20.19 | 11.9 | 0.0265 | 0.0223 | -0.1108 | 0.1112 | 1.3534 | 0.5062 |
| MCF 10A-H2B-mCherry | Neratinib | 21.90 | 11.9 | 0.0207 | 0.0191 | -0.1246 | 0.0444 | 1.2557 | 0.5569 |
| MCF 10A-H2B-mCherry | Taxol | 15.08 | 11.9 | 0.0045 | 0.019 | -0.5767 | -0.8583 | 0.7179 | 0.6695 |
| MCF 10A-H2B-mCherry | Trametinib | 54.25 | 11.9 | 0.0146 | 0.0184 | -0.1911 | -0.0833 | 1.2687 | 0.5001 |
| MCF 10A-H2B-mCherry | Trametinib | 52.56 | 11.9 | 0.0127 | 0.0135 | -0.1356 | -0.0271 | 0.9780 | 0.5060 |
| MCF 10A-H2B-mCherry | Taxol | 16.79 | 11.9 | 0.0027 | 0.0126 | -0.6222 | -0.8419 | 0.7095 | 0.7366 |
| MCF 10A-H2B-mCherry | Trametinib | 50.86 | 11.9 | 0.0107 | 0.012 | -0.1042 | -0.0310 | 0.9307 | 0.5301 |
| MCF 10A-H2B-mCherry | Trametinib | 49.15 | 11.9 | 0.0098 | 0.0101 | -0.0648 | -0.0012 | 1.0180 | 0.5326 |
| MCF 10A-H2B-mCherry | Trametinib | 47.45 | 11.9 | 0.0084 | 0.0086 | -0.0949 | -0.0113 | 1.0149 | 0.5557 |
| MCF 10A-H2B-mCherry | Trametinib | 45.74 | 11.9 | 0.0074 | 0.0071 | -0.0343 | 0.0191 | 0.9687 | 0.5652 |
| MCF 10A-H2B-mCherry | Trametinib | 40.63 | 11.9 | 0.0072 | 0.0068 | 0.0540 | 0.0361 | 1.0427 | 0.5699 |
| MCF 10A-H2B-mCherry | Trametinib | 44.03 | 11.9 | 0.007 | 0.0067 | 0.0180 | 0.0300 | 1.0037 | 0.5719 |
| MCF 10A-H2B-mCherry | Trametinib | 38.93 | 11.9 | 0.0062 | 0.0061 | 0.0264 | 0.0759 | 1.1491 | 0.5681 |
| MCF 10A-H2B-mCherry | Taxol | 18.49 | 11.9 | 0.0018 | 0.0057 | -0.6429 | -0.7171 | 0.7731 | 0.7994 |