LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 7 of 15: End-point dose-response metrics for biological replicate 1. - Dataset (ID:20315)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Neratinib | 60 | 0.1262 | 0.1133 | 0.0711 | 0.0699 | 1.4052 | 0.3452 |
| MCF 10A-H2B-mCherry | Neratinib | 74 | 0.1646 | 0.1622 | 0.0239 | 0.0094 | 1.2986 | 0.3339 |
| MCF 10A-H2B-mCherry | Neratinib | 85 | 0.2047 | 0.2231 | -0.0133 | -0.0516 | 1.1390 | 0.3213 |
| MCF 10A-H2B-mCherry | Palbociclib | 14 | Inf | 0.0470 | 0.6055 | 0.6286 | 2.3771 | 0.2335 |
| MCF 10A-H2B-mCherry | Palbociclib | 25 | 0.1608 | 0.0623 | 0.3195 | 0.3100 | 1.0196 | 0.4040 |
| MCF 10A-H2B-mCherry | Palbociclib | 36 | 0.216 | 0.1111 | 0.2237 | 0.2190 | 0.8662 | 0.3977 |
| MCF 10A-H2B-mCherry | Palbociclib | 49 | 0.2432 | 0.1490 | 0.1924 | 0.1866 | 0.9531 | 0.3867 |
| MCF 10A-H2B-mCherry | Palbociclib | 60 | 0.308 | 0.1983 | 0.1719 | 0.1611 | 0.8830 | 0.3696 |
| MCF 10A-H2B-mCherry | Palbociclib | 74 | 0.3799 | 0.2585 | 0.1562 | 0.1383 | 0.8411 | 0.3557 |
| MCF 10A-H2B-mCherry | Palbociclib | 85 | 0.4752 | 0.3445 | 0.1455 | 0.1140 | 0.8049 | 0.3379 |
| MCF 10A-H2B-mCherry | Taxol | 14 | 0.0086 | 0.0094 | -0.3292 | -0.2527 | 5.0000 | 0.4921 |
| MCF 10A-H2B-mCherry | Taxol | 25 | 0.006 | 0.0088 | -0.5788 | -0.5111 | 1.8512 | 0.6091 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0036 | 0.0060 | -0.6322 | -0.5696 | 1.4542 | 0.6936 |
| MCF 10A-H2B-mCherry | Taxol | 49 | 0.0026 | 0.0045 | -0.5907 | -0.5232 | 1.3137 | 0.7187 |
| MCF 10A-H2B-mCherry | Taxol | 60 | 0.0024 | 0.0038 | -0.5376 | -0.4605 | 1.4197 | 0.7151 |
| MCF 10A-H2B-mCherry | Taxol | 74 | 0.0023 | 0.0034 | -0.4930 | -0.4115 | 1.5424 | 0.7101 |
| MCF 10A-H2B-mCherry | Taxol | 85 | 0.0023 | 0.0033 | -0.4886 | -0.4051 | 1.6490 | 0.7131 |
| MCF 10A-H2B-mCherry | Trametinib | 14 | Inf | 0.0076 | 0.7513 | 0.8546 | 4.9986 | 0.0689 |
| MCF 10A-H2B-mCherry | Trametinib | 25 | 0.0129 | 0.0032 | 0.4248 | 0.4682 | 1.9686 | 0.3579 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | 0.0058 | 0.0031 | 0.2898 | 0.3109 | 1.5832 | 0.4664 |
| MCF 10A-H2B-mCherry | Trametinib | 49 | 0.0066 | 0.0040 | 0.2185 | 0.2369 | 1.2900 | 0.4933 |
| MCF 10A-H2B-mCherry | Trametinib | 60 | 0.0078 | 0.0050 | 0.1929 | 0.2064 | 1.1997 | 0.4918 |
| MCF 10A-H2B-mCherry | Trametinib | 74 | 0.0093 | 0.0062 | 0.1778 | 0.1846 | 1.1445 | 0.4863 |
| MCF 10A-H2B-mCherry | Trametinib | 85 | 0.0112 | 0.0077 | 0.1723 | 0.1730 | 1.1413 | 0.4734 |
| MCF 10A-H2B-mCherry | Vorinostat | 14 | 1.2267 | 0.9430 | 0.1980 | 0.1308 | 1.1529 | 0.2691 |