LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 7 of 15: End-point dose-response metrics for biological replicate 1. - Dataset (ID:20315)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 49 | 0.9385 | 1.0915 | -0.0683 | -0.1220 | 1.4457 | 0.3318 |
| MCF 10A-H2B-mCherry | Palbociclib | 49 | 0.2432 | 0.1490 | 0.1924 | 0.1866 | 0.9531 | 0.3867 |
| MCF 10A-H2B-mCherry | Taxol | 49 | 0.0026 | 0.0045 | -0.5907 | -0.5232 | 1.3137 | 0.7187 |
| MCF 10A-H2B-mCherry | Trametinib | 49 | 0.0066 | 0.0040 | 0.2185 | 0.2369 | 1.2900 | 0.4933 |
| MCF 10A-H2B-mCherry | Etoposide | 49 | 0.4668 | 0.4781 | 0.0158 | -0.0157 | 1.2947 | 0.3416 |
| MCF 10A-H2B-mCherry | Alpelisib | 49 | 24.7897 | 113.5315 | 0.6824 | -0.9254 | 0.6885 | 0.0557 |
| MCF 10A-H2B-mCherry | Dasatinib | 49 | 0.7746 | 1.1082 | 0.0954 | -0.1144 | 0.5751 | 0.3048 |
| MCF 10A-H2B-mCherry | Palbociclib | 60 | 0.308 | 0.1983 | 0.1719 | 0.1611 | 0.8830 | 0.3696 |
| MCF 10A-H2B-mCherry | Vorinostat | 60 | 1.0712 | 1.2024 | -0.0684 | -0.1062 | 1.6672 | 0.3109 |
| MCF 10A-H2B-mCherry | Taxol | 60 | 0.0024 | 0.0038 | -0.5376 | -0.4605 | 1.4197 | 0.7151 |
| MCF 10A-H2B-mCherry | Trametinib | 60 | 0.0078 | 0.0050 | 0.1929 | 0.2064 | 1.1997 | 0.4918 |
| MCF 10A-H2B-mCherry | Neratinib | 60 | 0.1262 | 0.1133 | 0.0711 | 0.0699 | 1.4052 | 0.3452 |
| MCF 10A-H2B-mCherry | Alpelisib | 60 | 26.0457 | 109.4817 | 0.6959 | -0.8810 | 0.7075 | 0.0512 |
| MCF 10A-H2B-mCherry | Dasatinib | 60 | 0.9634 | 4.3329 | 0.0547 | -0.5493 | 0.4931 | 0.3012 |
| MCF 10A-H2B-mCherry | Etoposide | 60 | 0.4484 | 0.4561 | 0.0206 | -0.0114 | 1.3240 | 0.3465 |
| MCF 10A-H2B-mCherry | Taxol | 74 | 0.0023 | 0.0034 | -0.4930 | -0.4115 | 1.5424 | 0.7101 |
| MCF 10A-H2B-mCherry | Vorinostat | 74 | 1.2172 | 1.3203 | -0.0640 | -0.0849 | 1.9279 | 0.2897 |
| MCF 10A-H2B-mCherry | Trametinib | 74 | 0.0093 | 0.0062 | 0.1778 | 0.1846 | 1.1445 | 0.4863 |
| MCF 10A-H2B-mCherry | Palbociclib | 74 | 0.3799 | 0.2585 | 0.1562 | 0.1383 | 0.8411 | 0.3557 |
| MCF 10A-H2B-mCherry | Alpelisib | 74 | 31.5401 | 177.9526 | 0.7039 | -1.0000 | 0.6349 | 0.0560 |
| MCF 10A-H2B-mCherry | Dasatinib | 74 | 1.127 | 11.8661 | 0.0188 | -1.0000 | 0.4667 | 0.2978 |
| MCF 10A-H2B-mCherry | Etoposide | 74 | 0.4441 | 0.4511 | 0.0118 | -0.0110 | 1.3847 | 0.3505 |
| MCF 10A-H2B-mCherry | Neratinib | 74 | 0.1646 | 0.1622 | 0.0239 | 0.0094 | 1.2986 | 0.3339 |
| MCF 10A-H2B-mCherry | Trametinib | 85 | 0.0112 | 0.0077 | 0.1723 | 0.1730 | 1.1413 | 0.4734 |
| MCF 10A-H2B-mCherry | Taxol | 85 | 0.0023 | 0.0033 | -0.4886 | -0.4051 | 1.6490 | 0.7131 |