Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 1850 937 0.2739 0.2129 0.5065 0.5118
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 515 127 0.1164 0.1044 0.2466 0.2680
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 446 133 0.0939 0.1044 0.2982 0.2680
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 463 120 0.1029 0.1044 0.2592 0.2680
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1256 291 0.2895 0.1794 0.2317 0.2428
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 774 191 0.1749 0.1794 0.2468 0.2428
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 328 82 0.0738 0.1794 0.2500 0.2428
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 364 75 0.0867 0.0797 0.2060 0.2019
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 360 69 0.0873 0.0797 0.1917 0.2019
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 274 57 0.0651 0.0797 0.2080 0.2019
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 3392 232 0.9378 1.0000 0.0684 0.0647
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 3799 234 1.0580 1.0000 0.0616 0.0647
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 3616 232 1.0043 1.0000 0.0642 0.0647
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 3878 235 1.0811 1.4011 0.0606 0.0616
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 5152 346 1.4263 1.4011 0.0672 0.0616
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 6061 346 1.6960 1.4011 0.0571 0.0616
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2752 288 0.7312 0.5728 0.1047 0.0984
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2177 201 0.5864 0.5728 0.0923 0.0984
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 1497 147 0.4006 0.5728 0.0982 0.0984
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2464 221 0.6656 0.5409 0.0897 0.0829
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2300 197 0.6241 0.5409 0.0857 0.0829
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1211 89 0.3330 0.5409 0.0735 0.0829
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 895 317 0.1715 0.2370 0.3542 0.3610
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 1381 495 0.2629 0.2370 0.3584 0.3610
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 1480 548 0.2766 0.2370 0.3703 0.3610