Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 3 293 135 0.1366 0.1795 0.4608 0.4353
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 482 229 0.2187 0.1726 0.4751 0.4923
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 396 198 0.1712 0.1726 0.5000 0.4923
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 3 297 149 0.1280 0.1726 0.5017 0.4923
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 1 538 201 0.2914 0.3084 0.3736 0.3843
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 2 603 242 0.3121 0.3084 0.4013 0.3843
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 3 598 226 0.3216 0.3084 0.3779 0.3843
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 1 512 220 0.2524 0.3023 0.4297 0.3999
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 2 618 238 0.3285 0.3023 0.3851 0.3999
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 3 613 236 0.3259 0.3023 0.3850 0.3999
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 1 544 229 0.2723 0.1951 0.4210 0.4396
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 2 359 152 0.1790 0.1951 0.4234 0.4396
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 3 295 140 0.1340 0.1951 0.4746 0.4396
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 1 374 194 0.1556 0.1329 0.5187 0.4906
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 2 330 152 0.1539 0.1329 0.4606 0.4906
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 3 203 100 0.0890 0.1329 0.4926 0.4906
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 1 455 191 0.2282 0.2939 0.4198 0.4176
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 2 637 275 0.3130 0.2939 0.4317 0.4176
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 3 658 264 0.3406 0.2939 0.4012 0.4176
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 1 494 200 0.2542 0.1712 0.4049 0.5833
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 2 158 157 0.0009 0.1712 0.9937 0.5833
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 3 461 162 0.2585 0.1712 0.3514 0.5833
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 1 504 233 0.2343 0.1784 0.4623 0.4506
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 2 361 159 0.1746 0.1784 0.4404 0.4506
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 3 265 119 0.1262 0.1784 0.4491 0.4506