Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 558 233 0.3138 0.3434 0.4176 0.4350
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 655 289 0.3534 0.3434 0.4412 0.4350
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 679 303 0.3631 0.3434 0.4462 0.4350
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 430 197 0.2250 0.1835 0.4581 0.4751
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 351 175 0.1699 0.1835 0.4986 0.4751
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 303 142 0.1555 0.1835 0.4686 0.4751
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 458 272 0.1796 0.1329 0.5939 0.6191
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 374 238 0.1313 0.1329 0.6364 0.6191
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 244 153 0.0879 0.1329 0.6270 0.6191
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 508 194 0.3032 0.3447 0.3819 0.4015
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 615 234 0.3679 0.3447 0.3805 0.4015
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 674 298 0.3631 0.3447 0.4421 0.4015
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 541 271 0.2607 0.3135 0.5009 0.4677
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 631 275 0.3437 0.3135 0.4358 0.4677
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 652 304 0.3360 0.3135 0.4663 0.4677
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 429 203 0.2182 0.1699 0.4732 0.5080
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 387 186 0.1941 0.1699 0.4806 0.5080
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 235 134 0.0975 0.1699 0.5702 0.5080
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 424 247 0.1709 0.1310 0.5825 0.6198
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 390 248 0.1371 0.1310 0.6359 0.6198
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 245 157 0.0850 0.1310 0.6408 0.6198
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 492 185 0.2964 0.3505 0.3760 0.4085
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 648 271 0.3640 0.3505 0.4182 0.4085
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 712 307 0.3911 0.3505 0.4312 0.4085
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 431 180 0.2424 0.2478 0.4176 0.4332