Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 1 1897 800 0.2732 0.2739 0.4217 0.4128
WM-115 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 2 1904 772 0.2819 0.2739 0.4055 0.4128
WM-115 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 3 1819 748 0.2667 0.2739 0.4112 0.4128
WM-115 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 1 1754 1074 0.1693 0.1546 0.6123 0.6149
WM-115 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 2 1532 949 0.1452 0.1546 0.6195 0.6149
WM-115 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 3 1550 950 0.1494 0.1546 0.6129 0.6149
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 1 1934 806 0.2809 0.2833 0.4168 0.3861
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 2 1782 684 0.2734 0.2833 0.3838 0.3861
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 3 1848 661 0.2956 0.2833 0.3577 0.3861
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 1 1919 823 0.2729 0.2611 0.4289 0.4263
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 2 1752 691 0.2642 0.2611 0.3944 0.4263
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 3 1817 828 0.2463 0.2611 0.4557 0.4263
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 1.0000
uM
 72
hr
 1 1762 712 0.2615 0.2470 0.4041 0.4117
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 1.0000
uM
 72
hr
 2 1683 680 0.2498 0.2470 0.4040 0.4117
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 1.0000
uM
 72
hr
 3 1611 688 0.2298 0.2470 0.4271 0.4117
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 1 1446 994 0.1126 0.1262 0.6874 0.6643
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 2 1738 1161 0.1437 0.1262 0.6680 0.6643
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 3 1354 863 0.1223 0.1262 0.6374 0.6643
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 1 1743 861 0.2196 0.2150 0.4940 0.5018
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 2 1798 915 0.2199 0.2150 0.5089 0.5018
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 3 1658 833 0.2054 0.2150 0.5024 0.5018
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.3160
uM
 72
hr
 1 1621 743 0.2186 0.1965 0.4584 0.4858
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.3160
uM
 72
hr
 2 1529 810 0.1790 0.1965 0.5298 0.4858
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.3160
uM
 72
hr
 3 1451 681 0.1917 0.1965 0.4693 0.4858
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 1 1661 896 0.1905 0.1847 0.5394 0.5321