Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 3291 599 0.4507 0.4939 0.1820 0.1677
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 3122 441 0.4488 0.4939 0.1413 0.1677
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 1264 695 0.0953 0.0919 0.5498 0.5808
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 1369 791 0.0968 0.0919 0.5778 0.5808
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 1295 796 0.0835 0.0919 0.6147 0.5808
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1029 874 0.0259 0.0288 0.8494 0.8392
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1080 895 0.0310 0.0288 0.8287 0.8392
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1096 920 0.0295 0.0288 0.8394 0.8392
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 977 892 0.0142 0.0131 0.9130 0.9136
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 878 799 0.0132 0.0131 0.9100 0.9136
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 850 780 0.0117 0.0131 0.9176 0.9136
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1194 1134 0.0100 0.0089 0.9497 0.9492
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1088 1033 0.0092 0.0089 0.9494 0.9492
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 855 811 0.0074 0.0089 0.9485 0.9492
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 1045 671 0.0626 0.0702 0.6421 0.6384
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1241 807 0.0727 0.0702 0.6503 0.6384
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1193 743 0.0753 0.0702 0.6228 0.6384
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 970 830 0.0234 0.0224 0.8557 0.8561
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 842 726 0.0194 0.0224 0.8622 0.8561
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 975 829 0.0244 0.0224 0.8503 0.8561
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 975 908 0.0112 0.0121 0.9313 0.9187
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 875 806 0.0116 0.0121 0.9211 0.9187
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 840 759 0.0136 0.0121 0.9036 0.9187
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 977 934 0.0072 0.0072 0.9560 0.9542
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 830 793 0.0062 0.0072 0.9554 0.9542