Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1237 839 0.0660 0.0672 0.6783 0.6856
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1432 1020 0.0683 0.0672 0.7123 0.6856
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 668 650 0.0030 0.0042 0.9731 0.9671
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 788 761 0.0045 0.0042 0.9657 0.9671
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 828 797 0.0051 0.0042 0.9626 0.9671
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1101 1055 0.0076 0.0072 0.9582 0.9576
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 965 921 0.0073 0.0072 0.9544 0.9576
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1029 988 0.0068 0.0072 0.9602 0.9576
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 779 744 0.0058 0.0069 0.9551 0.9524
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 919 876 0.0071 0.0069 0.9532 0.9524
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 898 852 0.0076 0.0069 0.9488 0.9524
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1235 921 0.0521 0.0529 0.7457 0.7685
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1402 1070 0.0551 0.0529 0.7632 0.7685
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1524 1214 0.0514 0.0529 0.7966 0.7685
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 618 601 0.0028 0.0029 0.9725 0.9759
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 712 695 0.0028 0.0029 0.9761 0.9759
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 914 895 0.0032 0.0029 0.9792 0.9759
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1164 1140 0.0040 0.0044 0.9794 0.9751
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1083 1059 0.0040 0.0044 0.9778 0.9751
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 1006 974 0.0053 0.0044 0.9682 0.9751
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 754 726 0.0046 0.0058 0.9629 0.9563
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 836 798 0.0063 0.0058 0.9545 0.9563
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 802 763 0.0065 0.0058 0.9514 0.9563
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1185 1072 0.0187 0.0156 0.9046 0.9275
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1118 1048 0.0116 0.0156 0.9374 0.9275