Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 543 237 0.2895 0.2718 0.4365 0.4581
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 461 178 0.2677 0.2397 0.3861 0.3798
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 386 136 0.2365 0.2397 0.3523 0.3798
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 379 152 0.2148 0.2397 0.4011 0.3798
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 687 233 0.4295 0.3166 0.3392 0.3298
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 505 166 0.3207 0.3166 0.3287 0.3298
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 311 100 0.1996 0.3166 0.3215 0.3298
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 450 137 0.2961 0.2904 0.3044 0.2383
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 383 70 0.2961 0.2904 0.1828 0.2383
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 382 87 0.2791 0.2904 0.2277 0.2383
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 1060 39 0.9858 1.0000 0.0368 0.0416
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 1068 50 0.9829 1.0000 0.0468 0.0416
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 1114 46 1.0312 1.0000 0.0413 0.0416
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1269 57 1.1703 1.3505 0.0449 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1538 67 1.4203 1.3505 0.0436 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1575 62 1.4609 1.3505 0.0394 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 725 32 0.6691 0.6350 0.0441 0.0435
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 710 32 0.6547 0.6350 0.0451 0.0435
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 628 26 0.5813 0.6350 0.0414 0.0435
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 954 37 0.8854 0.6505 0.0388 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 671 25 0.6238 0.6505 0.0373 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 483 25 0.4422 0.6505 0.0518 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 464 170 0.2839 0.3602 0.3664 0.3691
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 585 240 0.3331 0.3602 0.4103 0.3691
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 717 237 0.4635 0.3602 0.3305 0.3691