Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1700 674 0.2660 0.2794 0.3965 0.3819
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1717 659 0.2743 0.2794 0.3838 0.3819
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1811 662 0.2979 0.2794 0.3655 0.3819
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1710 598 0.2883 0.2819 0.3497 0.3543
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 1705 584 0.2906 0.2819 0.3425 0.3543
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 1635 606 0.2668 0.2819 0.3706 0.3543
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1478 571 0.2351 0.2287 0.3863 0.3702
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1469 527 0.2442 0.2287 0.3587 0.3702
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1258 460 0.2069 0.2287 0.3657 0.3702
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 1626 567 0.2745 0.2983 0.3487 0.3439
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1881 656 0.3176 0.2983 0.3488 0.3439
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1754 586 0.3028 0.2983 0.3341 0.3439
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 1456 648 0.2095 0.2121 0.4451 0.4516
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 1464 651 0.2108 0.2121 0.4447 0.4516
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 1557 724 0.2160 0.2121 0.4650 0.4516
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1504 618 0.2297 0.2175 0.4109 0.4311
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 1535 647 0.2302 0.2175 0.4215 0.4311
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1378 635 0.1926 0.2175 0.4608 0.4311
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1308 538 0.1996 0.1880 0.4113 0.4385
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1360 608 0.1950 0.1880 0.4471 0.4385
WM-115 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1203 550 0.1693 0.1880 0.4572 0.4385
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1653 730 0.2393 0.2566 0.4416 0.4382
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1807 780 0.2662 0.2566 0.4317 0.4382
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1824 805 0.2642 0.2566 0.4413 0.4382
WM-115 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1416 726 0.1789 0.1784 0.5127 0.4970