Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1001 952 0.0082 0.0072 0.9510 0.9542
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1228 917 0.0521 0.0484 0.7467 0.7812
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1298 1043 0.0427 0.0484 0.8035 0.7812
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1461 1159 0.0506 0.0484 0.7933 0.7812
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 828 740 0.0147 0.0144 0.8937 0.9001
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 818 740 0.0131 0.0144 0.9046 0.9001
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 939 847 0.0154 0.0144 0.9020 0.9001
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1103 1052 0.0085 0.0076 0.9538 0.9544
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1028 987 0.0069 0.0076 0.9601 0.9544
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 888 843 0.0075 0.0076 0.9493 0.9544
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 762 730 0.0054 0.0058 0.9580 0.9500
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 781 744 0.0062 0.0058 0.9526 0.9500
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 578 543 0.0059 0.0058 0.9394 0.9500
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1023 943 0.0134 0.0124 0.9218 0.9350
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 963 903 0.0100 0.0124 0.9377 0.9350
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 1504 1422 0.0137 0.0124 0.9455 0.9350
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 868 834 0.0057 0.0059 0.9608 0.9563
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 721 688 0.0055 0.0059 0.9542 0.9563
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 847 808 0.0065 0.0059 0.9540 0.9563
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1361 1317 0.0074 0.0051 0.9677 0.9739
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1171 1145 0.0044 0.0051 0.9778 0.9739
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 929 907 0.0037 0.0051 0.9763 0.9739
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 817 795 0.0037 0.0038 0.9731 0.9738
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 839 825 0.0023 0.0038 0.9833 0.9738
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 917 885 0.0054 0.0038 0.9651 0.9738