Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 473 442 0.0060 0.0058 0.9345 0.9410
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 2 581 559 0.0043 0.0058 0.9621 0.9410
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 3 490 454 0.0070 0.0058 0.9265 0.9410
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 1024 935 0.0173 0.0135 0.9131 0.9372
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 2 1107 1050 0.0111 0.0135 0.9485 0.9372
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 3 1238 1176 0.0121 0.0135 0.9499 0.9372
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 1 839 795 0.0086 0.0068 0.9476 0.9483
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 564 520 0.0086 0.0068 0.9220 0.9483
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 3 687 670 0.0033 0.0068 0.9753 0.9483
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 1274 1219 0.0107 0.0091 0.9568 0.9558
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 2 1075 1043 0.0062 0.0091 0.9702 0.9558
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 3 889 836 0.0103 0.0091 0.9404 0.9558
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 530 505 0.0049 0.0053 0.9528 0.9453
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 2 596 563 0.0064 0.0053 0.9446 0.9453
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 3 390 366 0.0047 0.0053 0.9385 0.9453
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 7559 1075 1.0855 1.0000 0.1422 0.1438
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 6943 1101 0.9780 1.0000 0.1586 0.1438
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 6434 840 0.9365 1.0000 0.1306 0.1438
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 4983 821 0.6968 0.8158 0.1648 0.1556
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 5368 854 0.7557 0.8158 0.1591 0.1556
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 6935 991 0.9951 0.8158 0.1429 0.1556
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 3916 531 0.5667 0.5804 0.1356 0.1393
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 4507 587 0.6563 0.5804 0.1302 0.1393
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 3650 555 0.5181 0.5804 0.1521 0.1393
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 4239 762 0.5821 0.4939 0.1798 0.1677