Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 883 391 0.1682 0.2605 0.4428 0.4310
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 3 883 235 0.1708 0.2238 0.2661 0.2477
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 3.1600
uM
 72
hr
 2 885 426 0.0894 0.0930 0.4814 0.4614
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 885 354 0.5024 0.4664 0.4000 0.4110
WM-115 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 2 887 702 0.0541 0.0559 0.7914 0.7596
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 888 162 0.0467 0.0378 0.1824 0.2000
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 888 843 0.0075 0.0076 0.9493 0.9544
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 3 889 836 0.0103 0.0091 0.9404 0.9558
A-375 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 3 889 206 0.0343 0.0372 0.2317 0.2503
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 890 196 0.0446 0.0429 0.2202 0.2266
WM-115 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 3 894 721 0.0496 0.0511 0.8065 0.8071
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 895 317 0.1715 0.2370 0.3542 0.3610
A-375 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 2 897 253 0.0324 0.0329 0.2821 0.2741
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 2 897 272 0.6188 0.5696 0.3032 0.3054
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 2 898 274 0.0314 0.0308 0.3051 0.3011
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 898 852 0.0076 0.0069 0.9488 0.9524
WM-115 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 3 899 623 0.0801 0.0936 0.6930 0.6738
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 903 859 0.0062 0.0055 0.9513 0.9565
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 1.0000
uM
 72
hr
 1 903 750 0.0375 0.0356 0.8306 0.8419
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 905 331 0.1962 0.1695 0.3657 0.3471
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 1.0000
uM
 72
hr
 2 905 762 0.0351 0.0356 0.8420 0.8419
WM-115 Vemurafenib Trametinib I-BET 1.0000 0.1000 1.0000
uM
 72
hr
 2 908 668 0.0702 0.0709 0.7357 0.7196
MZ7-mel Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 909 315 0.2030 0.1695 0.3465 0.3471
WM-115 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 1.0000
uM
 72
hr
 1 909 744 0.0473 0.0511 0.8185 0.8071
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 910 342 0.1941 0.2182 0.3758 0.3712