Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 2 654 466 0.0408 0.0457 0.7125 0.6841
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 654 138 0.0332 0.0378 0.2110 0.2000
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 655 239 0.4119 0.3026 0.3649 0.3593
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 655 91 0.1692 0.1255 0.1389 0.1549
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 655 289 0.3534 0.3434 0.4412 0.4350
MMAC-SF Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 658 312 0.3273 0.3617 0.4742 0.4540
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 3 658 264 0.3406 0.2939 0.4012 0.4176
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 658 136 0.0335 0.0378 0.2067 0.2000
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 659 180 0.4743 0.3693 0.2731 0.2801
COLO 858 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 2 659 510 0.0422 0.0452 0.7739 0.7587
MZ7-mel Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 3 665 336 0.0867 0.1575 0.5053 0.4835
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 668 650 0.0030 0.0042 0.9731 0.9671
MMAC-SF Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 670 245 0.4021 0.3649 0.3657 0.3754
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 671 25 0.6238 0.6505 0.0373 0.0426
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 671 295 0.3723 0.3271 0.4396 0.4508
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 672 253 0.4149 0.3739 0.3765 0.3865
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 674 298 0.3631 0.3447 0.4421 0.4015
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 678 256 0.3992 0.3787 0.3776 0.3840
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 679 303 0.3631 0.3434 0.4462 0.4350
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 3 680 598 0.0160 0.0182 0.8794 0.8649
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 683 654 0.0048 0.0066 0.9575 0.9516
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 683 22 0.6254 0.7364 0.0322 0.0453
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 0.3160
uM
 72
hr
 2 683 242 0.3813 0.3533 0.3543 0.3907
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 684 37 0.6406 0.7059 0.0541 0.0474
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 686 304 0.3782 0.3736 0.4431 0.4306