Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 628 26 0.5813 0.6350 0.0414 0.0435
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 3 628 198 0.4257 0.3924 0.3153 0.3351
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 628 100 0.0339 0.0441 0.1592 0.1675
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 631 275 0.3437 0.3135 0.4358 0.4677
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 3 631 237 0.3901 0.3640 0.3756 0.3926
MMAC-SF Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 3 633 208 0.4208 0.4000 0.3286 0.3246
COLO 858 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 3 635 409 0.0490 0.0457 0.6441 0.6841
COLO 858 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 1 635 476 0.0450 0.0452 0.7496 0.7587
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 2 637 275 0.3130 0.2939 0.4317 0.4176
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 1 638 221 0.4129 0.3924 0.3464 0.3351
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 639 159 0.0308 0.0336 0.2488 0.2228
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 3 641 523 0.0230 0.0246 0.8159 0.8210
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 641 287 0.1051 0.1162 0.4477 0.4480
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 0.0000
uM
 72
hr
 2 642 246 0.3424 0.3170 0.3832 0.3752
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 643 599 0.0062 0.0069 0.9316 0.9329
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 644 73 0.1713 0.1670 0.1134 0.1411
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 1 644 178 0.4614 0.3703 0.2764 0.2742
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 644 42 0.1806 0.3687 0.0652 0.0639
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 2 646 523 0.0240 0.0246 0.8096 0.8210
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 648 271 0.3640 0.3505 0.4182 0.4085
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 649 610 0.0076 0.0100 0.9399 0.9220
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 649 22 0.1881 0.2356 0.0339 0.0441
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 652 304 0.3360 0.3135 0.4663 0.4677
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 652 248 0.4000 0.3739 0.3804 0.3865
COLO 858 Vemurafenib Trametinib I-BET 1.0000 0.1000 1.0000
uM
 72
hr
 3 653 618 0.0099 0.0126 0.9464 0.9372