Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 606 254 0.3485 0.3366 0.4191 0.3769
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 2 606 506 0.0195 0.0182 0.8350 0.8649
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 607 206 0.3970 0.4683 0.3394 0.3301
MZ7-mel Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 2 608 291 0.0835 0.0835 0.4786 0.4574
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 608 126 0.0310 0.0336 0.2072 0.2228
MMAC-SF Vemurafenib Trametinib PF562271 0.1000 0.0100 0.3160
uM
 72
hr
 1 609 230 0.3277 0.3533 0.3777 0.3907
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 2 609 138 0.4663 0.4370 0.2266 0.2386
MMAC-SF Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 613 280 0.3150 0.3557 0.4568 0.4268
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 613 215 0.3941 0.4462 0.3507 0.3627
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 3 613 236 0.3259 0.3023 0.3850 0.3999
COLO 858 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 2 615 570 0.0127 0.0086 0.9268 0.9481
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 615 234 0.3679 0.3447 0.3805 0.4015
MMAC-SF Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 616 234 0.3614 0.3649 0.3799 0.3754
COLO 858 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 1 617 518 0.0215 0.0184 0.8395 0.8831
MMAC-SF Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 2 617 189 0.4238 0.4000 0.3063 0.3246
MMAC-SF Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 2 618 238 0.3285 0.3023 0.3851 0.3999
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 618 601 0.0028 0.0029 0.9725 0.9759
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 2 619 148 0.4663 0.4300 0.2391 0.2490
COLO 858 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 3 620 597 0.0065 0.0086 0.9629 0.9481
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 620 276 0.3406 0.3271 0.4452 0.4508
COLO 858 Vemurafenib Trametinib I-BET 3.1600 0.3160 0.0000
uM
 72
hr
 1 622 530 0.0261 0.0176 0.8521 0.8960
MMAC-SF Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 623 194 0.4059 0.3491 0.3114 0.3549
MMAC-SF Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 2 624 248 0.3723 0.3729 0.3974 0.4100
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 626 614 0.0020 0.0020 0.9808 0.9824
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 626 580 0.0065 0.0069 0.9265 0.9329