Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 367 103 0.2614 0.3693 0.2807 0.2801
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 857 266 0.5851 0.4168 0.3104 0.2703
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 534 145 0.3851 0.4168 0.2715 0.2703
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 367 84 0.2802 0.4168 0.2289 0.2703
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 551 237 0.3109 0.3736 0.4301 0.4306
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 686 304 0.3782 0.3736 0.4431 0.4306
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 750 314 0.4317 0.3736 0.4187 0.4306
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 613 215 0.3941 0.4462 0.3507 0.3627
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 789 282 0.5020 0.4462 0.3574 0.3627
MMAC-SF Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 765 270 0.4901 0.3766 0.3529 0.3292