Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 15518 786 0.8751 0.8466 0.0507 0.0510
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 13521 729 0.7598 0.8466 0.0539 0.0510
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 16139 705 0.9168 1.0000 0.0437 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 18289 776 1.0403 1.0000 0.0424 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 18392 833 1.0430 1.0000 0.0453 0.0438
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 831 38 0.7851 1.0000 0.0457 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 1129 54 1.0644 1.0000 0.0478 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 1203 41 1.1505 1.0000 0.0341 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1256 52 1.1921 1.3614 0.0414 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1549 78 1.4564 1.3614 0.0504 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1533 83 1.4356 1.3614 0.0541 0.0486
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 945 46 0.8901 0.7459 0.0487 0.0510
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 873 43 0.8218 0.7459 0.0493 0.0510
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 562 31 0.5257 0.7459 0.0552 0.0510
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 1004 46 0.9485 0.7521 0.0458 0.0500
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 872 37 0.8267 0.7521 0.0424 0.0500
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 518 32 0.4812 0.7521 0.0618 0.0500
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 519 209 0.3069 0.3739 0.4027 0.3865
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 652 248 0.4000 0.3739 0.3804 0.3865
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 672 253 0.4149 0.3739 0.3765 0.3865
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 607 206 0.3970 0.4683 0.3394 0.3301
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 724 222 0.4970 0.4683 0.3066 0.3301
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 787 271 0.5109 0.4683 0.3443 0.3301
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 659 180 0.4743 0.3693 0.2731 0.2801
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 527 151 0.3723 0.3693 0.2865 0.2801