Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1767 946 0.2167 0.2059 0.5354 0.5413
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1607 889 0.1895 0.2059 0.5532 0.5413
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 1200 666 0.1409 0.1457 0.5550 0.5805
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 1323 813 0.1346 0.1457 0.6145 0.5805
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 1430 818 0.1615 0.1457 0.5720 0.5805
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 1382 737 0.1702 0.1935 0.5333 0.5386
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1546 825 0.1903 0.1935 0.5336 0.5386
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1846 1013 0.2198 0.1935 0.5488 0.5386
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 1900 967 0.2462 0.2302 0.5089 0.4981
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 1654 800 0.2254 0.2302 0.4837 0.4981
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1666 836 0.2191 0.2302 0.5018 0.4981
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1919 848 0.2827 0.2644 0.4419 0.4438
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1792 811 0.2589 0.2644 0.4526 0.4438
WM-115 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1694 740 0.2518 0.2644 0.4368 0.4438
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1345 692 0.1723 0.1786 0.5145 0.5384
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1445 784 0.1745 0.1786 0.5426 0.5384
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1620 904 0.1890 0.1786 0.5580 0.5384
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1461 733 0.1921 0.2108 0.5017 0.4999
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 1583 777 0.2127 0.2108 0.4908 0.4999
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1749 887 0.2275 0.2108 0.5071 0.4999
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 1747 827 0.2428 0.2416 0.4734 0.4746
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 1756 806 0.2507 0.2416 0.4590 0.4746
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 1722 846 0.2312 0.2416 0.4913 0.4746
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1970 760 0.3193 0.3049 0.3858 0.3755
WM-115 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1987 748 0.3270 0.3049 0.3764 0.3755