Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1083 745 0.0792 0.0725 0.6879 0.7217
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 836 361 0.4494 0.4664 0.4318 0.4110
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 885 354 0.5024 0.4664 0.4000 0.4110
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 556 172 0.3633 0.3784 0.3094 0.3086
MMAC-SF Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 755 321 0.4106 0.3557 0.4252 0.4268
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1153 685 0.1097 0.1154 0.5941 0.5851
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 1187 684 0.1179 0.1154 0.5762 0.5851
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 875 41 0.7890 0.7329 0.0469 0.0348
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1219 713 0.1186 0.1154 0.5849 0.5851
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 2503 345 0.1387 0.1297 0.1378 0.1366
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 2058 623 0.3365 0.3340 0.3027 0.3130
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 506 12 0.4674 0.7329 0.0237 0.0348
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1238 740 0.1168 0.1322 0.5977 0.5586
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 772 164 0.0391 0.0336 0.2124 0.2228
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 1344 776 0.1332 0.1322 0.5774 0.5586
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 1252 627 0.1465 0.1322 0.5008 0.5586
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 2433 341 0.1344 0.1297 0.1402 0.1366
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 2070 643 0.3346 0.3340 0.3106 0.3130
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 1031 35 0.9423 0.7329 0.0339 0.0348
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 586 214 0.3519 0.3787 0.3652 0.3840
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 2384 556 0.4286 0.4016 0.2332 0.2480
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1368 883 0.1137 0.1195 0.6455 0.6100
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 950 52 0.8496 0.7364 0.0547 0.0453
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1235 921 0.0521 0.0529 0.7457 0.7685
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1402 1070 0.0551 0.0529 0.7632 0.7685