Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2100 97 0.1287 0.1268 0.0462 0.0491
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1432 1020 0.0683 0.0672 0.7123 0.6856
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 788 761 0.0045 0.0042 0.9657 0.9671
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 668 650 0.0030 0.0042 0.9731 0.9671
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 524 165 0.3396 0.3844 0.3149 0.3169
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2843 489 0.5519 0.5260 0.1720 0.1772
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 608 126 0.0310 0.0336 0.2072 0.2228
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2254 446 0.4239 0.4392 0.1979 0.1684
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2129 338 0.4199 0.4392 0.1588 0.1684
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 1240 173 NaN NaN NaN NaN
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1368 883 0.1137 0.1195 0.6455 0.6100
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 885 354 0.5024 0.4664 0.4000 0.4110
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 514 160 0.3349 0.3844 0.3113 0.3169
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 2874 628 0.5266 0.5131 0.2185 0.2141
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 4717 279 0.2852 0.2809 0.0591 0.0601
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 2741 592 0.5039 0.5131 0.2160 0.2141
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 2739 569 0.5088 0.5131 0.2077 0.2141
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 1356 203 NaN NaN NaN NaN
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2644 476 0.5083 0.5260 0.1800 0.1772
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 836 361 0.4494 0.4664 0.4318 0.4110
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2691 483 0.5177 0.5260 0.1795 0.1772
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 639 159 0.0308 0.0336 0.2488 0.2228
WM-115 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1302 783 0.1217 0.1195 0.6014 0.6100
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 3039 126 0.1872 0.1595 0.0415 0.0410
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1280 253 NaN NaN NaN NaN