Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 1250 219 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 2248 244 0.1288 0.1325 0.1085 0.1040
A-375 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 1 17620 818 0.8443 0.9140 0.0464 0.0504
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1427 243 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 941 182 0.0488 0.0503 0.1934 0.1892
A-375 Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1947 361 0.0897 0.0851 0.1854 0.1871
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1027 243 NaN NaN NaN NaN
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2100 97 0.1287 0.1268 0.0462 0.0491
A-375 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 1108 292 0.0410 0.0372 0.2635 0.2503
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 19308 1026 1.0346 1.0000 0.0531 0.0517
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 888 162 0.0467 0.0378 0.1824 0.2000
A-375 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 1519 457 0.0601 0.0503 0.3009 0.3253
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 15081 869 0.8042 0.8521 0.0576 0.0546
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 766 180 0.0377 0.0429 0.2350 0.2266
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1986 341 0.0931 0.0813 0.1717 0.1656
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 9628 474 0.5180 0.5111 0.0492 0.0493
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1031 185 0.0544 0.0441 0.1794 0.1675
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 772 164 0.0391 0.0336 0.2124 0.2228
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2870 305 0.1452 0.1203 0.1063 0.1099
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 3999 254 0.2407 0.2809 0.0635 0.0601
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1460 527 0.0528 0.0486 0.3610 0.3602
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 2530 245 0.1293 0.1257 0.0968 0.0985
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 2079 274 0.1160 0.1297 0.1318 0.1366
A-375 Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 1 1969 305 0.0836 0.0767 0.1549 0.1498
A-375 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 1 2061 256 0.0907 0.0972 0.1242 0.1264