Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 757 701 0.0109 0.0100 0.9260 0.9220
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 888 162 0.0467 0.0378 0.1824 0.2000
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.3160
uM
 72
hr
 1 1621 743 0.2186 0.1965 0.4584 0.4858
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 1 1098 711 0.0754 0.0780 0.6475 0.6507
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 2318 206 0.1255 0.1286 0.0889 0.0918
A-375 Vemurafenib Trametinib Belinostat 0.1000 0.0100 0.0000
uM
 72
hr
 1 1343 219 0.0850 0.0947 0.1631 0.1614
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 1 930 774 0.0304 0.0311 0.8323 0.8371
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 1 11842 391 0.6751 0.6666 0.0330 0.0291
A-375 Vemurafenib Trametinib Belinostat 0.3160 0.0316 1.0000
uM
 72
hr
 1 1213 756 0.0346 0.0461 0.6232 0.4969
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 1 831 716 0.0224 0.0212 0.8616 0.8626
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1677 174 0.0893 0.0914 0.1038 0.1080
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 473 442 0.0060 0.0058 0.9345 0.9410
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 1 483 442 0.0080 0.0074 0.9151 0.9225
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 15081 869 0.8042 0.8521 0.0576 0.0546
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 1024 935 0.0173 0.0135 0.9131 0.9372
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 1 1025 747 0.0541 0.0539 0.7288 0.7310
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1282 177 0.0656 0.0610 0.1381 0.1316
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 766 180 0.0377 0.0429 0.2350 0.2266
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 1 828 729 0.0193 0.0182 0.8804 0.8649
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 6910 334 0.3877 0.3181 0.0483 0.0472
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 1274 1219 0.0107 0.0091 0.9568 0.9558
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 1 1154 1069 0.0166 0.0145 0.9263 0.9198
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1074 145 0.0552 0.0473 0.1350 0.1511
A-375 Vemurafenib Trametinib I-BET 0.3160 0.0316 0.0000
uM
 72
hr
 1 1557 185 0.0985 0.0967 0.1188 0.1087
A-375 Vemurafenib Trametinib I-BET 0.1000 0.0100 1.0000
uM
 72
hr
 1 1689 436 0.0899 0.0821 0.2581 0.2731