Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 2285 305 0.1176 0.1298 0.1335 0.1284
A-375 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 1 2521 533 0.1172 0.0979 0.2114 0.2134
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 849 828 0.0035 0.0045 0.9753 0.9731
A-375 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1792 210 0.0940 0.0978 0.1172 0.1134
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2870 305 0.1452 0.1203 0.1063 0.1099
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 1 1025 747 0.0541 0.0539 0.7288 0.7310
A-375 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1559 204 0.0805 0.0712 0.1309 0.1272
A-375 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 1 1881 473 0.0830 0.0712 0.2515 0.2626
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1337 1219 0.0196 0.0145 0.9117 0.9231
A-375 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 1246 181 0.0633 0.0502 0.1453 0.1455
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 3999 254 0.2407 0.2809 0.0635 0.0601
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 779 744 0.0058 0.0069 0.9551 0.9524
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 2462 353 0.1253 0.1328 0.1434 0.1351
A-375 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 1 2404 241 0.1275 0.1366 0.1002 0.1053
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 668 650 0.0030 0.0042 0.9731 0.9671
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 1779 195 0.0941 0.0889 0.1096 0.1191
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 2530 245 0.1293 0.1257 0.0968 0.0985
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1101 1055 0.0076 0.0072 0.9582 0.9576
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1675 277 0.0830 0.0738 0.1654 0.1567
A-375 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 1 2013 415 0.0942 0.1084 0.2062 0.1812
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 618 601 0.0028 0.0029 0.9725 0.9759
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1083 214 0.0516 0.0479 0.1976 0.1891
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 2079 274 0.1160 0.1297 0.1318 0.1366
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1202 841 0.0953 0.0943 0.6997 0.7022
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1419 848 0.1507 0.1496 0.5976 0.5838