Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 941 182 0.0488 0.0503 0.1934 0.1892
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 969 853 0.0272 0.0294 0.8803 0.8675
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 2793 297 0.1254 0.1292 0.1063 0.1109
A-375 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 2401 434 0.1113 0.0927 0.1808 0.1858
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 754 726 0.0046 0.0058 0.9629 0.9563
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 1 2412 298 0.1062 0.1004 0.1235 0.1324
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1027 243 NaN NaN NaN NaN
WM-115 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1700 674 0.2660 0.2794 0.3965 0.3819
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 2244 392 0.0931 0.0785 0.1747 0.1769
A-375 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1752 499 0.0709 0.0542 0.2848 0.3430
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 711 706 0.0008 0.0020 0.9930 0.9824
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 963 266 0.0350 0.0308 0.2762 0.3011
A-375 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2100 97 0.1287 0.1268 0.0462 0.0491
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 7512 1166 0.8932 0.9286 0.1552 0.1630
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 18392 833 1.0430 1.0000 0.0453 0.0438
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 1 17534 924 0.9793 1.0000 0.0527 0.0484
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 707 693 0.0023 0.0030 0.9802 0.9776
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 13521 729 0.7598 0.8466 0.0539 0.0510
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 19308 1026 1.0346 1.0000 0.0531 0.0517
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 8737 1282 1.0493 1.0000 0.1467 0.1477
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 9338 344 0.5342 0.4663 0.0368 0.0378
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 1 15733 557 0.8947 1.0240 0.0354 0.0404
WM-115 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 1092 570 0.1353 0.1465 0.5220 0.4850
WM-115 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 1 1876 768 0.2759 0.2823 0.4094 0.4075
WM-115 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 1 1948 617 0.3315 0.3286 0.3167 0.3294