Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Belinostat 1.0000 0.1000 1.0000
uM
 72
hr
 1 1168 689 0.0362 0.0445 0.5899 0.4923
A-375 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 2 983 257 0.0365 0.0344 0.2614 0.2734
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1246 986 0.0366 0.0435 0.7913 0.7870
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 872 714 0.0370 0.0413 0.8188 0.7970
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 1003 844 0.0373 0.0392 0.8415 0.8497
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 1.0000
uM
 72
hr
 1 903 750 0.0375 0.0356 0.8306 0.8419
A-375 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 1.0000
uM
 72
hr
 1 1400 886 0.0376 0.0338 0.6329 0.6400
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 766 180 0.0377 0.0429 0.2350 0.2266
A-375 Vemurafenib Trametinib Belinostat 0.3160 0.0316 1.0000
uM
 72
hr
 2 1222 718 0.0381 0.0461 0.5876 0.4969
A-375 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1100 421 0.0384 0.0422 0.3827 0.3824
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 772 164 0.0391 0.0336 0.2124 0.2228
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 742 124 0.0397 0.0393 0.1671 0.1867
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 806 134 0.0399 0.0473 0.1663 0.1511
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1149 978 0.0401 0.0392 0.8512 0.8497
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1197 1025 0.0403 0.0392 0.8563 0.8497
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 804 126 0.0403 0.0422 0.1567 0.1591
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1435 1146 0.0407 0.0458 0.7986 0.7801
COLO 858 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 2 654 466 0.0408 0.0457 0.7125 0.6841
A-375 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 804 113 0.0410 0.0502 0.1405 0.1455
A-375 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 1108 292 0.0410 0.0372 0.2635 0.2503
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 1161 986 0.0410 0.0413 0.8493 0.8498
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 1 1222 950 0.0411 0.0438 0.7774 0.7578
COLO 858 Vemurafenib Trametinib I-BET151 0.1000 0.0100 1.0000
uM
 72
hr
 1 1284 1116 0.0412 0.0438 0.8692 0.8476
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 817 124 0.0412 0.0422 0.1518 0.1591
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 783 607 0.0413 0.0413 0.7752 0.7970