Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 3 1154 939 0.0325 0.0327 0.8137 0.8107
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1504 1272 0.0327 0.0247 0.8457 0.8594
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 1154 921 0.0328 0.0310 0.7981 0.8160
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 3 1061 844 0.0328 0.0438 0.7955 0.7578
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 1.0000
uM
 72
hr
 1 1403 1186 0.0328 0.0286 0.8453 0.8489
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 1201 965 0.0332 0.0310 0.8035 0.8160
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 654 138 0.0332 0.0378 0.2110 0.2000
A-375 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 3 1175 720 0.0333 0.0409 0.6128 0.5956
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1328 1091 0.0334 0.0295 0.8215 0.8149
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 658 136 0.0335 0.0378 0.2067 0.2000
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 1 1033 589 0.0336 0.0434 0.5702 0.4431
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.3160
uM
 72
hr
 1 1151 927 0.0338 0.0327 0.8054 0.8107
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 628 100 0.0339 0.0441 0.1592 0.1675
COLO 858 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 1 830 691 0.0341 0.0282 0.8325 0.8552
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 1.0000
uM
 72
hr
 3 946 807 0.0341 0.0356 0.8531 0.8419
A-375 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 3 889 206 0.0343 0.0372 0.2317 0.2503
A-375 Vemurafenib Trametinib Belinostat 0.3160 0.0316 1.0000
uM
 72
hr
 1 1213 756 0.0346 0.0461 0.6232 0.4969
A-375 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 1 937 246 0.0347 0.0329 0.2625 0.2741
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 3 1042 864 0.0347 0.0311 0.8292 0.8371
COLO 858 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 2 1075 933 0.0348 0.0411 0.8679 0.8294
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 963 266 0.0350 0.0308 0.2762 0.3011
COLO 858 Vemurafenib Trametinib I-BET151 1.0000 0.1000 1.0000
uM
 72
hr
 2 905 762 0.0351 0.0356 0.8420 0.8419
A-375 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 1.0000
uM
 72
hr
 2 1324 842 0.0352 0.0338 0.6360 0.6400
A-375 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 994 279 0.0359 0.0344 0.2807 0.2734
A-375 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 966 247 0.0361 0.0372 0.2557 0.2503