Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 1 1491 1204 0.0433 0.0226 0.8075 0.8932
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1237 1209 0.0046 0.0049 0.9774 0.9743
A-375 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 2 21851 1210 1.0372 1.0000 0.0554 0.0502
COLO 858 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1524 1214 0.0514 0.0529 0.7966 0.7685
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 1274 1219 0.0107 0.0091 0.9568 0.9558
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1337 1219 0.0196 0.0145 0.9117 0.9231
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 3 1402 1236 0.0251 0.0186 0.8816 0.9092
COLO 858 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 0.0000
uM
 72
hr
 3 1579 1242 0.0509 0.0532 0.7866 0.7386
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1598 1262 0.0473 0.0435 0.7897 0.7870
COLO 858 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 1 1324 1269 0.0157 0.0146 0.9585 0.9538
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1504 1272 0.0327 0.0247 0.8457 0.8594
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 8737 1282 1.0493 1.0000 0.1467 0.1477
A-375 Vemurafenib Trametinib Belinostat 0.0000 0.0000 0.0000
uM
 72
hr
 1 12722 1293 0.8641 1.0000 0.1016 0.1003
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1361 1317 0.0074 0.0051 0.9677 0.9739
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1706 1317 0.0548 0.0458 0.7720 0.7801
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 2 1412 1324 0.0133 0.0186 0.9377 0.9092
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 8236 1331 0.9719 0.9286 0.1616 0.1630
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 2 1414 1345 0.0104 0.0226 0.9512 0.8932
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 9127 1356 1.0938 1.0000 0.1486 0.1477
COLO 858 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1387 1358 0.0048 0.0049 0.9791 0.9743
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 7902 1360 0.9208 0.9286 0.1721 0.1630
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1549 1404 0.0204 0.0153 0.9064 0.9147
COLO 858 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 1504 1422 0.0137 0.0124 0.9455 0.9350
A-375 Vemurafenib Trametinib I-BET151 0.0000 0.0000 0.0000
uM
 72
hr
 1 15278 1501 0.9565 1.0000 0.0982 0.1003
A-375 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 0.0000
uM
 72
hr
 2 14936 1503 0.9820 1.0000 0.1006 0.0658