Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 2 1148 850 0.0742 0.0736 0.7404 0.7638
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 985 850 0.0190 0.0247 0.8629 0.8594
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 3 1826 852 0.2395 0.2157 0.4666 0.4582
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 1454 852 0.1589 0.1604 0.5860 0.5766
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 898 852 0.0076 0.0069 0.9488 0.9524
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1436 853 0.1539 0.1496 0.5940 0.5838
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 969 853 0.0272 0.0294 0.8803 0.8675
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 5368 854 0.7557 0.8158 0.1591 0.1556
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 1367 855 0.0721 0.0704 0.6255 0.6512
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 3 1191 855 0.0507 0.0470 0.7179 0.7476
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 1234 857 0.0995 0.0943 0.6945 0.7022
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 903 859 0.0062 0.0055 0.9513 0.9565
COLO 858 Vemurafenib Trametinib I-BET 0.3160 0.0316 1.0000
uM
 72
hr
 2 914 861 0.0150 0.0166 0.9420 0.9313
WM-115 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 1 1743 861 0.2196 0.2150 0.4940 0.5018
WM-115 Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 3 1354 863 0.1223 0.1262 0.6374 0.6643
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 3 1042 864 0.0347 0.0311 0.8292 0.8371
WM-115 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 1483 865 0.1631 0.1604 0.5833 0.5766
MZ7-mel Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 3 1688 868 0.2161 0.1960 0.5142 0.5353
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 15081 869 0.8042 0.8521 0.0576 0.0546
COLO 858 Vemurafenib Trametinib I-BET 0.0000 0.0000 0.0000
uM
 72
hr
 3 4941 870 1.1528 1.0000 0.1761 0.1901
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 1.0000
uM
 72
hr
 2 9244 871 0.6009 0.5962 0.0942 0.0732
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1029 874 0.0259 0.0288 0.8494 0.8392
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 2 1340 875 0.0702 0.0732 0.6530 0.6424
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 2 6192 876 1.0352 1.0000 0.1415 0.1347
WM-115 Vemurafenib Trametinib I-BET151 0.1000 0.0100 1.0000
uM
 72
hr
 2 1296 876 0.1219 0.1185 0.6759 0.6600