Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 274 57 0.0651 0.0797 0.2080 0.2019
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 1 1157 57 0.9510 1.0000 0.0493 0.0504
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 342 58 0.0852 0.1670 0.1696 0.1411
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1014 59 0.2865 0.3534 0.0582 0.0527
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 1062 60 0.9480 1.0000 0.0565 0.0561
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 3 1057 61 0.9861 1.0000 0.0577 0.0533
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 414 61 0.1059 0.1797 0.1473 0.1476
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 307 62 0.0735 0.1255 0.2020 0.1549
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1575 62 1.4609 1.3505 0.0394 0.0426
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 1102 62 1.0297 1.0000 0.0563 0.0533
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 509 63 0.1338 0.1255 0.1238 0.1549
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 1390 63 1.3139 1.3106 0.0453 0.0383
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 2 1187 63 0.9718 1.0000 0.0531 0.0504
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 3 1310 64 1.0772 1.0000 0.0489 0.0504
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1538 67 1.4203 1.3505 0.0436 0.0426
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 1064 67 0.2991 0.2356 0.0630 0.0441
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 360 69 0.0873 0.0797 0.1917 0.2019
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1474 69 1.3292 1.3504 0.0468 0.0554
MMAC-SF Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 3 328 69 0.2564 0.2729 0.2104 0.2392
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 383 70 0.2961 0.2904 0.1828 0.2383
MZ7-mel Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 644 73 0.1713 0.1670 0.1134 0.1411
MZ7-mel Vemurafenib Trametinib Dasatinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 364 75 0.0867 0.0797 0.2060 0.2019
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 1712 76 1.4144 1.2637 0.0444 0.0426
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1710 77 0.4899 0.3534 0.0450 0.0527
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1549 78 1.4564 1.3614 0.0504 0.0486