Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 1 1192 39 0.9968 1.2637 0.0327 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 1060 39 0.9858 1.0000 0.0368 0.0416
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 816 40 0.7342 0.7364 0.0490 0.0453
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 2 859 40 0.7081 0.6202 0.0466 0.0473
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 1203 41 1.1505 1.0000 0.0341 0.0425
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 875 41 0.7890 0.7329 0.0469 0.0348
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 644 42 0.1806 0.3687 0.0652 0.0639
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 873 43 0.8218 0.7459 0.0493 0.0510
MZ7-mel Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 299 45 0.0762 0.1798 0.1505 0.1885
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 1446 46 1.3861 1.3106 0.0318 0.0383
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 1004 46 0.9485 0.7521 0.0458 0.0500
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 1114 46 1.0312 1.0000 0.0413 0.0416
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 945 46 0.8901 0.7459 0.0487 0.0510
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 1032 48 0.9743 0.7059 0.0465 0.0474
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 999 48 0.8997 1.0000 0.0480 0.0561
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 1 1042 48 0.9842 1.0000 0.0461 0.0533
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 1 1293 49 1.2317 1.3106 0.0379 0.0383
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 344 50 0.0882 0.1849 0.1453 0.1624
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 1068 50 0.9829 1.0000 0.0468 0.0416
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1256 52 1.1921 1.3614 0.0414 0.0486
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 950 52 0.8496 0.7364 0.0547 0.0453
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 1129 54 1.0644 1.0000 0.0478 0.0425
MZ7-mel Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 412 55 0.1071 0.1325 0.1335 0.1632
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1001 55 0.2838 0.3534 0.0549 0.0527
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1269 57 1.1703 1.3505 0.0449 0.0426