Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib (+)-JQ1 1.0000 0.1000 0.0000
uM
 72
hr
 1 1633 176 0.1065 0.1126 0.1078 0.0954
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1342 176 0.0693 0.0610 0.1311 0.1313
MMAC-SF Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 1.0000
uM
 72
hr
 1 546 177 0.3653 0.2710 0.3242 0.3368
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1805 177 0.4221 0.4571 0.0981 0.0908
A-375 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 1176 177 0.0593 0.0712 0.1505 0.1272
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1282 177 0.0656 0.0610 0.1381 0.1316
A-375 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 959 178 NaN NaN NaN NaN
MZ7-mel Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 3 3220 178 0.7480 0.8065 0.0553 0.0577
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 461 178 0.2677 0.2397 0.3861 0.3798
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 3.1600
uM
 72
hr
 1 644 178 0.4614 0.3703 0.2764 0.2742
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 0.0000
uM
 72
hr
 3 1482 178 0.0986 0.1011 0.1201 0.1391
A-375 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 0.0000
uM
 72
hr
 1 1502 178 0.0968 0.0919 0.1185 0.1179
MZ7-mel Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 3 958 179 0.1916 0.2350 0.1868 0.2157
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 2 521 179 0.3386 0.3924 0.3436 0.3351
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 1534 179 0.0805 0.0866 0.1167 0.1048
MMAC-SF Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 659 180 0.4743 0.3693 0.2731 0.2801
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2655 180 0.6416 0.6483 0.0678 0.0808
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 431 180 0.2424 0.2478 0.4176 0.4332
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 766 180 0.0377 0.0429 0.2350 0.2266
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 747 181 0.1680 0.3046 0.2423 0.2351
A-375 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 1246 181 0.0633 0.0502 0.1453 0.1455
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 4796 182 0.2741 0.3895 0.0379 0.0403
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2060 182 0.4869 0.4571 0.0883 0.0908
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 471 182 0.2790 0.1986 0.3864 0.4158
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 941 182 0.0488 0.0503 0.1934 0.1892