Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Belinostat 1.0000 0.1000 0.0000
uM
 72
hr
 2 1755 165 0.1202 0.1127 0.0940 0.1173
MMAC-SF Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 340 166 0.1504 0.1236 0.4882 0.4924
MMAC-SF Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 505 166 0.3207 0.3166 0.3287 0.3298
MZ7-mel Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 797 166 0.1893 0.1798 0.2083 0.1885
MMAC-SF Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 2 356 167 0.1634 0.1628 0.4691 0.4419
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 376 167 0.2018 0.2053 0.4441 0.4547
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1951 168 0.4622 0.4571 0.0861 0.0908
A-375 Vemurafenib Trametinib Saracatinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 926 169 0.0450 0.0479 0.1825 0.1891
MZ7-mel Vemurafenib Trametinib Saracatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 441 169 0.0930 0.2403 0.3832 0.3512
MMAC-SF Vemurafenib Trametinib Saracatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 521 169 0.3485 0.3073 0.3244 0.3388
A-375 Vemurafenib Trametinib (+)-JQ1 3.1600 0.3160 0.0000
uM
 72
hr
 3 1408 169 0.0906 0.0919 0.1200 0.1179
A-375 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 1 1626 169 0.1046 0.1045 0.1039 0.1185
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 3564 170 0.8945 0.9655 0.0477 0.0440
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 464 170 0.2839 0.3602 0.3664 0.3691
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 1 687 172 0.5099 0.4370 0.2504 0.2386
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 556 172 0.3633 0.3784 0.3094 0.3086
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 956 173 0.0503 0.0503 0.1810 0.1892
A-375 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 1240 173 NaN NaN NaN NaN
MMAC-SF Vemurafenib Trametinib JNK-IN-8 1.0000 0.1000 3.1600
uM
 72
hr
 1 584 174 0.4059 0.3373 0.2979 0.2733
MMAC-SF Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 585 174 0.3888 0.3299 0.2974 0.2945
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1677 174 0.0893 0.0914 0.1038 0.1080
MMAC-SF Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 351 175 0.1699 0.1835 0.4986 0.4751
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 1 698 175 0.5178 0.4300 0.2507 0.2490
A-375 Vemurafenib Trametinib I-BET151 3.1600 0.3160 0.0000
uM
 72
hr
 2 1567 175 0.0966 0.1079 0.1117 0.1023
A-375 Vemurafenib Trametinib (+)-JQ1 0.3160 0.0316 0.0000
uM
 72
hr
 2 1502 175 0.0970 0.1055 0.1165 0.0998