Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 564 520 0.0086 0.0068 0.9220 0.9483
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 898 852 0.0076 0.0069 0.9488 0.9524
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 779 744 0.0058 0.0069 0.9551 0.9524
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 958 901 0.0080 0.0069 0.9405 0.9329
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 626 580 0.0065 0.0069 0.9265 0.9329
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 643 599 0.0062 0.0069 0.9316 0.9329
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 919 876 0.0071 0.0069 0.9532 0.9524
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 1 1068 1016 0.0079 0.0070 0.9513 0.9543
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 2 1126 1078 0.0072 0.0070 0.9574 0.9543
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 3.1600
uM
 72
hr
 3 872 832 0.0060 0.0070 0.9541 0.9543
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 977 934 0.0072 0.0072 0.9560 0.9542
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1029 988 0.0068 0.0072 0.9602 0.9576
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1001 952 0.0082 0.0072 0.9510 0.9542
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 965 921 0.0073 0.0072 0.9544 0.9576
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1101 1055 0.0076 0.0072 0.9582 0.9576
COLO 858 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 830 793 0.0062 0.0072 0.9554 0.9542
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 1 483 442 0.0080 0.0074 0.9151 0.9225
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 2 481 450 0.0060 0.0074 0.9356 0.9225
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 3 505 463 0.0082 0.0074 0.9168 0.9225
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 888 843 0.0075 0.0076 0.9493 0.9544
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1103 1052 0.0085 0.0076 0.9538 0.9544
COLO 858 Vemurafenib Trametinib Saracatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1028 987 0.0069 0.0076 0.9601 0.9544
COLO 858 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 3 620 597 0.0065 0.0086 0.9629 0.9481
COLO 858 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 2 615 570 0.0127 0.0086 0.9268 0.9481
COLO 858 Vemurafenib Trametinib I-BET 3.1600 0.3160 1.0000
uM
 72
hr
 1 506 483 0.0065 0.0086 0.9545 0.9481