Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 766 180 0.0377 0.0429 0.2350 0.2266
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 1 1033 589 0.0336 0.0434 0.5702 0.4431
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 2 1083 387 0.0526 0.0434 0.3573 0.4431
A-375 Vemurafenib Trametinib Belinostat 3.1600 0.3160 1.0000
uM
 72
hr
 3 971 390 0.0439 0.0434 0.4016 0.4431
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1598 1262 0.0473 0.0435 0.7897 0.7870
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1246 986 0.0366 0.0435 0.7913 0.7870
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1509 1177 0.0467 0.0435 0.7800 0.7870
COLO 858 Vemurafenib Trametinib I-BET151 0.1000 0.0100 1.0000
uM
 72
hr
 2 1189 951 0.0584 0.0438 0.7998 0.8476
COLO 858 Vemurafenib Trametinib I-BET151 0.1000 0.0100 1.0000
uM
 72
hr
 3 1031 901 0.0319 0.0438 0.8739 0.8476
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 2 1272 891 0.0575 0.0438 0.7005 0.7578
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 3 1107 827 0.0423 0.0438 0.7471 0.7492
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 3 1061 844 0.0328 0.0438 0.7955 0.7578
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 1 1226 930 0.0447 0.0438 0.7586 0.7492
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 2 1143 848 0.0445 0.0438 0.7419 0.7492
COLO 858 Vemurafenib Trametinib I-BET151 0.1000 0.0100 1.0000
uM
 72
hr
 1 1284 1116 0.0412 0.0438 0.8692 0.8476
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 1.0000
uM
 72
hr
 1 1222 950 0.0411 0.0438 0.7774 0.7578
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 628 100 0.0339 0.0441 0.1592 0.1675
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 818 134 0.0440 0.0441 0.1638 0.1675
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1031 185 0.0544 0.0441 0.1794 0.1675
A-375 Vemurafenib Trametinib Belinostat 1.0000 0.1000 1.0000
uM
 72
hr
 3 1003 584 0.0317 0.0445 0.5823 0.4923
A-375 Vemurafenib Trametinib Belinostat 1.0000 0.1000 1.0000
uM
 72
hr
 1 1168 689 0.0362 0.0445 0.5899 0.4923
A-375 Vemurafenib Trametinib Belinostat 1.0000 0.1000 1.0000
uM
 72
hr
 2 1247 380 0.0656 0.0445 0.3047 0.4923
COLO 858 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 2 659 510 0.0422 0.0452 0.7739 0.7587
COLO 858 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 1 635 476 0.0450 0.0452 0.7496 0.7587
COLO 858 Vemurafenib Trametinib I-BET 1.0000 0.1000 0.0000
uM
 72
hr
 3 691 520 0.0484 0.0452 0.7525 0.7587