Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1197 1025 0.0403 0.0392 0.8563 0.8497
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 1003 844 0.0373 0.0392 0.8415 0.8497
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 519 103 0.0267 0.0393 0.1985 0.1867
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 742 124 0.0397 0.0393 0.1671 0.1867
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 997 194 0.0516 0.0393 0.1946 0.1867
A-375 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 3 1175 720 0.0333 0.0409 0.6128 0.5956
A-375 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 1 1532 909 0.0455 0.0409 0.5933 0.5956
A-375 Vemurafenib Trametinib (+)-JQ1 0.1000 0.0100 1.0000
uM
 72
hr
 2 1431 831 0.0439 0.0409 0.5807 0.5956
COLO 858 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 3 841 652 0.0464 0.0411 0.7753 0.8294
COLO 858 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 2 1075 933 0.0348 0.0411 0.8679 0.8294
COLO 858 Vemurafenib Trametinib I-BET151 0.3160 0.0316 1.0000
uM
 72
hr
 1 1104 933 0.0420 0.0411 0.8451 0.8294
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 1289 1112 0.0415 0.0413 0.8627 0.8498
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 1161 986 0.0410 0.0413 0.8493 0.8498
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 961 766 0.0457 0.0413 0.7971 0.7970
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 1083 907 0.0413 0.0413 0.8375 0.8498
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 783 607 0.0413 0.0413 0.7752 0.7970
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 872 714 0.0370 0.0413 0.8188 0.7970
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 913 154 0.0451 0.0422 0.1687 0.1591
A-375 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1100 421 0.0384 0.0422 0.3827 0.3824
A-375 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1232 483 0.0424 0.0422 0.3920 0.3824
A-375 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1286 479 0.0457 0.0422 0.3725 0.3824
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 817 124 0.0412 0.0422 0.1518 0.1591
A-375 Vemurafenib Trametinib Saracatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 804 126 0.0403 0.0422 0.1567 0.1591
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 890 196 0.0446 0.0429 0.2202 0.2266
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 931 209 0.0464 0.0429 0.2245 0.2266