Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 5474 256 1.3752 0.9655 0.0468 0.0440
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 1064 67 0.2991 0.2356 0.0630 0.0441
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 649 22 0.1881 0.2356 0.0339 0.0441
MZ7-mel Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 759 27 0.2196 0.2356 0.0356 0.0441
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 816 40 0.7342 0.7364 0.0490 0.0453
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 950 52 0.8496 0.7364 0.0547 0.0453
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 683 22 0.6254 0.7364 0.0322 0.0453
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 2976 138 0.7480 0.9208 0.0464 0.0457
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 3923 164 0.9907 0.9208 0.0418 0.0457
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 1 4085 200 1.0239 0.9208 0.0490 0.0457
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 4651 226 0.2609 0.3181 0.0486 0.0472
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 5428 243 0.3057 0.3181 0.0448 0.0472
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 6910 334 0.3877 0.3181 0.0483 0.0472
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 794 27 0.6631 0.6202 0.0340 0.0473
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 3 603 37 0.4893 0.6202 0.0614 0.0473
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 2 859 40 0.7081 0.6202 0.0466 0.0473
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 530 22 0.5030 0.7059 0.0415 0.0474
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 1032 48 0.9743 0.7059 0.0465 0.0474
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 684 37 0.6406 0.7059 0.0541 0.0474
A-375 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 3 10528 496 0.5041 0.5122 0.0471 0.0480
A-375 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 11357 569 0.5421 0.5122 0.0501 0.0480
A-375 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 2 10238 479 0.4904 0.5122 0.0468 0.0480
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 3 17907 936 1.0006 1.0000 0.0523 0.0484
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 18030 727 1.0201 1.0000 0.0403 0.0484
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 1 17534 924 0.9793 1.0000 0.0527 0.0484