Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib Belinostat 0.1000 0.0100 0.0000
uM
 72
hr
 1 1343 219 0.0850 0.0947 0.1631 0.1614
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 344 50 0.0882 0.1849 0.1453 0.1624
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1176 229 0.2841 0.1849 0.1947 0.1624
MZ7-mel Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 713 105 0.1824 0.1849 0.1473 0.1624
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 8236 1331 0.9719 0.9286 0.1616 0.1630
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 7902 1360 0.9208 0.9286 0.1721 0.1630
COLO 858 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 7512 1166 0.8932 0.9286 0.1552 0.1630
MZ7-mel Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 412 55 0.1071 0.1325 0.1335 0.1632
MZ7-mel Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 597 115 0.1446 0.1325 0.1926 0.1632
MZ7-mel Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 581 95 0.1458 0.1325 0.1635 0.1632
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 3 7119 1168 1.1589 0.9999 0.1641 0.1645
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 1 5080 829 0.8278 0.9999 0.1632 0.1645
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 6237 1036 1.0129 0.9999 0.1661 0.1645
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 1429 231 0.0678 0.0813 0.1617 0.1656
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 1751 286 0.0829 0.0813 0.1633 0.1656
A-375 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1986 341 0.0931 0.0813 0.1717 0.1656
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 628 100 0.0339 0.0441 0.1592 0.1675
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 818 134 0.0440 0.0441 0.1638 0.1675
A-375 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1031 185 0.0544 0.0441 0.1794 0.1675
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 4239 762 0.5821 0.4939 0.1798 0.1677
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 3291 599 0.4507 0.4939 0.1820 0.1677
COLO 858 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 3122 441 0.4488 0.4939 0.1413 0.1677
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2374 353 0.4739 0.4392 0.1487 0.1684
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2254 446 0.4239 0.4392 0.1979 0.1684
WM-115 Vemurafenib Trametinib Dasatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2129 338 0.4199 0.4392 0.1588 0.1684