Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 1060 39 0.9858 1.0000 0.0368 0.0416
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 1114 46 1.0312 1.0000 0.0413 0.0416
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 1129 54 1.0644 1.0000 0.0478 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 831 38 0.7851 1.0000 0.0457 0.0425
MMAC-SF Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 1203 41 1.1505 1.0000 0.0341 0.0425
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 1575 62 1.4609 1.3505 0.0394 0.0426
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 1 1192 39 0.9968 1.2637 0.0327 0.0426
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 2 1712 76 1.4144 1.2637 0.0444 0.0426
MMAC-SF Vemurafenib Trametinib PF562271 0.0000 0.0000 0.3160
uM
 72
hr
 3 1681 85 1.3798 1.2637 0.0506 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 671 25 0.6238 0.6505 0.0373 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 954 37 0.8854 0.6505 0.0388 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 1269 57 1.1703 1.3505 0.0449 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 483 25 0.4422 0.6505 0.0518 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 1538 67 1.4203 1.3505 0.0436 0.0426
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 628 26 0.5813 0.6350 0.0414 0.0435
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 725 32 0.6691 0.6350 0.0441 0.0435
MMAC-SF Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 710 32 0.6547 0.6350 0.0451 0.0435
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 579 23 0.5505 0.6713 0.0397 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 16139 705 0.9168 1.0000 0.0437 0.0438
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 735 34 0.6941 0.6713 0.0463 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 18289 776 1.0403 1.0000 0.0424 0.0438
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 1 814 37 0.7693 0.6713 0.0455 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 18392 833 1.0430 1.0000 0.0453 0.0438
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 3564 170 0.8945 0.9655 0.0477 0.0440
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 5474 256 1.3752 0.9655 0.0468 0.0440