Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 2779 239 0.6585 0.6483 0.0860 0.0808
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 2729 242 0.6447 0.6483 0.0887 0.0808
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 2655 180 0.6416 0.6483 0.0678 0.0808
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 2 2431 184 0.6441 0.6307 0.0757 0.0825
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 1 2490 221 0.6505 0.6307 0.0888 0.0825
WM-115 Vemurafenib Trametinib (+)-JQ1 0.0000 0.0000 1.0000
uM
 72
hr
 3 2273 189 0.5974 0.6307 0.0832 0.0825
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2300 197 0.6241 0.5409 0.0857 0.0829
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 2464 221 0.6656 0.5409 0.0897 0.0829
MZ7-mel Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 1211 89 0.3330 0.5409 0.0735 0.0829
A-375 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 2 7782 655 0.4948 0.5250 0.0842 0.0831
A-375 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 3 7321 587 0.4675 0.5250 0.0802 0.0831
A-375 Vemurafenib Trametinib I-BET151 0.0000 0.0000 1.0000
uM
 72
hr
 1 9641 818 0.6126 0.5250 0.0848 0.0831
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 3 2722 220 0.6603 0.7205 0.0808 0.0832
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 3249 292 0.7804 0.7205 0.0899 0.0832
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 2965 234 0.7208 0.7205 0.0789 0.0832
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 0.0000
uM
 72
hr
 3 14201 1526 0.9096 1.0000 0.1075 0.0842
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 0.0000
uM
 72
hr
 2 16108 728 1.1037 1.0000 0.0452 0.0842
A-375 Vemurafenib Trametinib I-BET 0.0000 0.0000 0.0000
uM
 72
hr
 1 15279 1529 0.9867 1.0000 0.1001 0.0842
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 3 2538 211 0.5691 0.5869 0.0831 0.0856
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 1 2821 227 0.6344 0.5869 0.0805 0.0856
WM-115 Vemurafenib Trametinib PF562271 0.0000 0.0000 1.0000
uM
 72
hr
 2 2513 234 0.5573 0.5869 0.0931 0.0856
A-375 Vemurafenib Trametinib I-BET 0.1000 0.0100 0.0000
uM
 72
hr
 3 1678 145 0.1100 0.1110 0.0864 0.0898
A-375 Vemurafenib Trametinib I-BET 0.1000 0.0100 0.0000
uM
 72
hr
 2 1704 156 0.1111 0.1110 0.0915 0.0898
A-375 Vemurafenib Trametinib I-BET 0.1000 0.0100 0.0000
uM
 72
hr
 1 1717 157 0.1119 0.1110 0.0914 0.0898
WM-115 Vemurafenib Trametinib Defactinib 0.0000 0.0000 3.1600
uM
 72
hr
 2 1951 168 0.4622 0.4571 0.0861 0.0908