Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 0.0000
uM
 72
hr
 2 1181 655 0.1024 0.0986 0.5546 0.5504
COLO 858 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 1410 841 0.0944 0.0996 0.5965 0.5798
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 2793 297 0.1254 0.1292 0.1063 0.1109
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 2 2857 325 0.1272 0.1292 0.1138 0.1109
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 3 3028 341 0.1350 0.1292 0.1126 0.1109
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 2 1412 1324 0.0133 0.0186 0.9377 0.9092
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 2 6192 876 1.0352 1.0000 0.1415 0.1347
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 1 1254 1139 0.0174 0.0186 0.9083 0.9092
MMAC-SF Vemurafenib Trametinib Dasatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 1062 60 0.9480 1.0000 0.0565 0.0561
COLO 858 Vemurafenib Trametinib JNK-IN-8 3.1600 0.3160 0.0000
uM
 72
hr
 3 1402 1236 0.0251 0.0186 0.8816 0.9092
COLO 858 Vemurafenib Trametinib PF562271 0.0000 0.0000 0.0000
uM
 72
hr
 1 6256 795 1.0635 1.0000 0.1271 0.1347
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 689 282 0.3851 0.3787 0.4093 0.3840
MMAC-SF Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 678 256 0.3992 0.3787 0.3776 0.3840
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 2277 237 0.1311 0.1325 0.1041 0.1040
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 18392 833 1.0430 1.0000 0.0453 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 18289 776 1.0403 1.0000 0.0424 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 16139 705 0.9168 1.0000 0.0437 0.0438
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 18030 727 1.0201 1.0000 0.0403 0.0484
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 19308 1026 1.0346 1.0000 0.0531 0.0517
A-375 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 3 17907 936 1.0006 1.0000 0.0523 0.0484
MMAC-SF Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 600 239 0.3415 0.3557 0.3983 0.4268
A-375 Vemurafenib Trametinib Defactinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 19509 973 1.0489 1.0000 0.0499 0.0517
COLO 858 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1432 1020 0.0683 0.0672 0.7123 0.6856
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 492 185 0.2964 0.3505 0.3760 0.4085
MMAC-SF Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 674 298 0.3631 0.3447 0.4421 0.4015