Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 2 609 138 0.4663 0.4370 0.2266 0.2386
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 649 610 0.0076 0.0100 0.9399 0.9220
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 1564 988 0.0811 0.0901 0.6317 0.5765
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 2 1533 890 0.0905 0.0901 0.5806 0.5765
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.0000
uM
 72
hr
 1 1452 751 0.0987 0.0901 0.5172 0.5765
WM-115 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 1 1960 722 0.3083 0.3088 0.3684 0.3580
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 742 124 0.0397 0.0393 0.1671 0.1867
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 3 416 107 0.3059 0.4300 0.2572 0.2490
A-375 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.0000
uM
 72
hr
 3 2461 233 0.1323 0.1286 0.0947 0.0918
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 3 444 106 0.3347 0.4370 0.2387 0.2386
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 3 789 223 0.5604 0.5696 0.2826 0.3054
A-375 Vemurafenib Trametinib Dasatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 997 194 0.0516 0.0393 0.1946 0.1867
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 1 799 264 0.5297 0.5696 0.3304 0.3054
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 2 897 272 0.6188 0.5696 0.3032 0.3054
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 1 698 175 0.5178 0.4300 0.2507 0.2490
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 855 811 0.0074 0.0089 0.9485 0.9492
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 1 638 221 0.4129 0.3924 0.3464 0.3351
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1194 1134 0.0100 0.0089 0.9497 0.9492
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1088 1033 0.0092 0.0089 0.9494 0.9492
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 2 521 179 0.3386 0.3924 0.3436 0.3351
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 977 892 0.0142 0.0131 0.9130 0.9136
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 878 799 0.0132 0.0131 0.9100 0.9136
WM-115 Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 2 2124 785 0.3334 0.3306 0.3696 0.3500
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1096 920 0.0295 0.0288 0.8394 0.8392
COLO 858 Vemurafenib Trametinib Saracatinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 850 780 0.0117 0.0131 0.9176 0.9136